Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

This study is currently recruiting participants.

Verified by Washington University School of Medicine, July 2008

Sponsored by:	Washington University School of Medicine
Information provided by:	Washington University School of Medicine
ClinicalTrials.gov Identifier:	NCT00565903

Purpose

Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB is not defined. We are working to identify the genetic factors which may contribute to the development of this rare tumor.

Condition
Pleuropulmonary Blastoma Cystic Nephroma

MedlinePlus related topics: Cancer

U.S. FDA Resources

Study Type:	Observational
Study Design:	Family-Based, Prospective
Official Title:	Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:

Identify the genetic factors which contribute to the development or progression of pleuropulmonary blastoma [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Define the clinical features of the pleuropulmonary blastoma (PPB) familial cancer syndrome. [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples With DNA

Biospecimen Description:

We are collecting blood samples or saliva samples. When available, we also collect tumor samples from prior surgical procedures.

Estimated Enrollment:	2000
Study Start Date:	March 2005
Estimated Study Completion Date:	March 2015

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Families who have a child or adult with pleuropulmonary blastoma or cystic nephroma are invited to participate.

Criteria

Inclusion Criteria:

child or adult diagnosed with pleuropulmonary blastoma or cystic nephroma.

Exclusion Criteria:

child or adult who does not have a confirmed diagnosis of pleuropulmonary blastoma or cystic nephroma.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00565903

Contacts

Contact: D. Ashley Hill, M.D.	314-454-8854	hill@path.wustl.edu
Contact: Jennifer L. Ivanovich, MS, MBA	314-454-5076	jen@ccadmin.wustl.edu

Locations

United States, Missouri
Washington University School of Medicine	Recruiting
St. Louis, Missouri, United States, 63110
Contact: D. Ashley Hill, MD 314-454-8854 hill@path.wustl.edu
Contact: Jennifer Ivanovich, MS, MBA 314-454-5076 jen@ccadmin.wustl.edu
Principal Investigator: D. Ashley Hill, MD
Sub-Investigator: Jennifer Ivanovich, MS, MBA
Sub-Investigator: Paul Goodfellow, PHD

Sponsors and Collaborators

Washington University School of Medicine

Investigators

Principal Investigator:	D. Ashley Hill, MD	Washington University Schoolo of Medicine
Study Chair:	Jennifer Ivanovich, MS, MBA	Washington University School of Medicine
Study Chair:	Paul Goodfellow, PhD	Washington University School of Medicine
Study Chair:	Jack Priest, MD	Children's Hospital and Clinics of Minnesota

More Information

PPB Research Program website This link exits the ClinicalTrials.gov site

Responsible Party:	Washington University School of Medicine ( D. Ashley, Hill, MD )
Study ID Numbers:	05-0192
Study First Received:	November 29, 2007
Last Updated:	July 31, 2008
ClinicalTrials.gov Identifier:	NCT00565903
Health Authority:	United States: Institutional Review Board

Keywords provided by Washington University School of Medicine:

pleuropulmonary blastoma
PPB
cystic nephroma

Study placed in the following topic categories:

Thoracic Neoplasms
Pleuropulmonary blastoma
Pulmonary Blastoma
Lung Neoplasms
Blastoma

Additional relevant MeSH terms:

Respiratory Tract Neoplasms
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type
Neoplasms, Complex and Mixed

ClinicalTrials.gov processed this record on January 15, 2009