Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Università degli Studi dell'Insubria |
---|---|
Information provided by: | Università degli Studi dell'Insubria |
ClinicalTrials.gov Identifier: | NCT00564057 |
Human immunodeficiency virus infection and highly active antiretroviral therapy (HAART) are associated with an increased risk of cardiovascular disease: a wide range of alterations in lipid and glucose metabolism has been increasingly recognized in HIV patients treated with HAART. Few data are available on the effects of antihypertensive treatment on cardiac morpho-functional characteristics and metabolic parameters in HIV patients. Aim of the study is to assess the effects of chronic therapy with angiotensin receptor blocker(candesartan)or calcium channel blocker (lercanidipine)on metabolic profile and cardiac remodelling in HIV hypertensive patients.
Condition | Intervention | Phase |
---|---|---|
HIV Infections Hypertension |
Drug: candesartan Drug: lercanidipine |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Effects of Antihypertensive Treatment on Cardiac Remodelling and Metabolic Profile in HIV Infected Patients: Randomized Longitudinal Study With Candesartan Versus Lercanidipine |
Estimated Enrollment: | 30 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | September 2009 |
Arms | Assigned Interventions |
---|---|
1: Experimental
candesartan 8-16 mg once daily
|
Drug: candesartan
tablet 8-16 mg once daily, one year
|
2: Active Comparator
lercanidipine 10-20 mg once daily
|
Drug: lercanidipine
tablets 10-20 mg once daily, one year
|
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: anna maria grandi, MD | +39 0332 278403 | amgrandi@libero.it |
Italy | |
University of Insubria, Department of Clinical Medicine | Recruiting |
Varese, Italy, 21100 |
Study Chair: | anna maria grandi, MD | University of Insubria, Varese, ITALY |
Principal Investigator: | paolo grossi, MD | University of Insubria, Varese, Italy |
Principal Investigator: | andrea maria maresca, MD | University of Insubria, Varese, Italy |
Principal Investigator: | eleonora nicolini, MD | University of Insubria, Varese, Italy |
Principal Investigator: | massimo giola, MD | University of Insubria, Varese, Italy |
Study ID Numbers: | 44758 |
Study First Received: | November 26, 2007 |
Last Updated: | December 5, 2007 |
ClinicalTrials.gov Identifier: | NCT00564057 |
Health Authority: | Italy: Ethics Committee |
HIV blood pressure left ventricle metabolic profile treatment experienced |
Sexually Transmitted Diseases, Viral Lercanidipine Acquired Immunodeficiency Syndrome Vascular Diseases Angiotensin II Immunologic Deficiency Syndromes Virus Diseases |
Candesartan cilexetil Calcium, Dietary HIV Infections Sexually Transmitted Diseases Candesartan Retroviridae Infections Hypertension |
RNA Virus Infections Slow Virus Diseases Immune System Diseases Molecular Mechanisms of Pharmacological Action Calcium Channel Blockers Cardiovascular Agents Infection |
Antihypertensive Agents Pharmacologic Actions Membrane Transport Modulators Angiotensin II Type 1 Receptor Blockers Therapeutic Uses Lentivirus Infections Cardiovascular Diseases |