Outcomes - Secondary/Late Effects of Treatment
Secondary or late effects are conditions that arise as a consequence of the diagnosis and treatment of cancer.
The number of cancer survivors in the US is increasing and this research seeks to understand the impact of cancer
and cancer treatment on survivors' health status and health outcomes. Survivors are faced with issues related
to follow-up care, long term surveillance for late effects of treatment, and the appropriate follow-up and treatment
for these late effects.
RRSS investigators are conducting studies to:
- investigate pregnancy outcomes in childhood cancer survivors
and in cervical cancer survivors;
- examine the health status of men diagnosed with testicular cancer
and long-term complications resulting from treatment;
- examine secondary tumors related to cancer treatment and the
natural history of prostate and colon cancer.
Registries Funded to Conduct these Studies
Atlanta (Metropolitan)
Detroit (Metropolitan)
Iowa
Los Angeles
New Mexico
Seattle (Puget Sound)
Utah
Key Findings
Treatment of cervical carcinoma in situ (CIS) may have an
impact on subsequent pregnancy outcomes. The risk of preterm delivery
increased after conization for CIS but did not increase when women
with CIS had other procedures. Treatments investigated included
no therapy, dilation and curettage or endocervical curettage, cryosurgery
or laser vaporization, and conization (El-Bastawissi, 1999).
Data collected on long-term survivors of testicular cancer indicate
that some therapies may have complications some time after the initial
treatment. However, the feasibility study does not have sufficient
numbers to draw conclusions.
Future Use
Investigators will pursue RO1 funding based on
feasibility studies conducted with this mechanism.
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