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| Sponsored by: |
IRCCS San Raffaele |
|---|---|
| Information provided by: | IRCCS San Raffaele |
| ClinicalTrials.gov Identifier: | NCT00520962 |
Purpose
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and atherosclerosis.
The following classes of subjects at high risk will be considered:First degree relatives of patients with type 2 diabetes mellitus, patients with cardiovascular disease and stroke, patients with heart valve disease. age will be > 30 years, both gender.
| Condition |
|---|
|
Diabetes Mellitus, Type 2 |
| Study Type: | Observational |
| Study Design: | Screening, Cross-Sectional, Defined Population, Prospective Study |
| Official Title: | New Physiopathogenics Mechanisms Susceptible of Pharmacological Developments (Insulin Resistance and Atherosclerosis) |
| Enrollment: | 1997 |
| Study Start Date: | June 1997 |
| Study Completion Date: | May 2006 |
| Groups/Cohorts |
|---|
1,2,3: Case
|
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4: Control
Healthy controls
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The primary outcome of the study is evaluation of glucose tolerance, insulin sensitivity and insulin secretion before and 2 hours post-glucose load Secondary outcomes are evaluation of endothelial function, of natriuretic peptides and free fatty acids, and inflammation before and 2 hours post-glucose load. New candidate genes will be also evaluated.
Eligibility| Ages Eligible for Study: | 30 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Italy | |
| Medicine Division, Diabetology, Endocrinology and Metabolic Disease Unit, IRCCS San Raffaele | |
| Milan, Italy, 20132 | |
| Principal Investigator: | PierMarco Piatti, MD | IRCSS San Raffaele |
More Information
| Study ID Numbers: | 199402-1369/516 |
| Study First Received: | August 24, 2007 |
| Last Updated: | August 24, 2007 |
| ClinicalTrials.gov Identifier: | NCT00520962 |
| Health Authority: | Italy: Ministry of Health |
|
cardiovascular disease glucose intolerance type 2 diabetes endothelial dysfunction |
inflammation Age> 30 years, male and female Fasting glucose below 126 mg/dl |
|
Atherosclerosis Metabolic Diseases Glucose Intolerance Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases |
Endocrinopathy Insulin Resistance Metabolic disorder Glucose Metabolism Disorders Insulin Inflammation |
