Sun, Y., Tao, Y.G., Kagan, B.L., He, Y., and Simons, S.S. Jr., "Modulation of transcription parameters by cofactors is similar for glucocorticoid receptor-mediated repression and induction." Mol. Cell. Endo., 295, 59-69 (2008).
Simons, S.S. Jr., "The Biology and Biochemistry of Steroid Hormones." Wiley Encyclopedia of Chemical Biology" Published on-line (2008). [invited]
Simons, S.S. Jr., "What goes on behind closed doors: physiological vs. pharmacological steroid hormone actions." BioEssays, 30, 744-756 (2008) [invited]
Tao, Y.G., Xu, Y., Xu, H.E., and Simons, S.S. Jr., "Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression." Biochemistry, 47, 7648-7662 (2008).
Suino-Powell, K., Xu, Y., Zhang, C., Tao, Y.G., Tolbert, W.D., Simons, S.S. Jr., and Xu, H.E., "Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol." Mol. Cell. Biol., 28, 1915-1923 (2008).
Szapary, D., Song, L-N. He, Y., and Simons, S.S. Jr., "Differential modulation of glucocorticoid and progesterone receptor transactivation." Mol. Cell. Endo., 283, 114-126 (2008).
Wang, D., Wang, Q., Awasthi, S., and Simons, S.S. Jr., "Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors." Biochemistry, 46, 8036-8049 (2007).
He Y, Simons SS Jr STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. Mol Cell Biol(27): 1467-85, 2007. [Full Text/Abstract]
Kim Y, Sun Y, Chow C, Pommier YG, Simons SS Jr Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. J Steroid Biochem Mol Biol(100): 3-17, 2006. [Full Text/Abstract]
Simons SS Jr How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor. Curr Top Med Chem(6): 271-85, 2006. [Full Text/Abstract]
Wang D, Simons SS Jr Corepressor Binding to Progesterone and Glucocorticoid Receptors Involves the AF-1 Domain and Is Inhibited by Molybdate. Mol Endocrinol , 2005. [Full Text/Abstract]
Cho S, Kagan BL, Blackford JA Jr, Szapary D, Simons SS Jr Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9. Mol Endocrinol (19): 290-311, 2005. [Full Text/Abstract]
Cho S, Blackford JA Jr, Simons SS Jr Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes. Biochemistry (44): 3547-61, 2005. [Full Text/Abstract]
Wang Q Blackford JA Jr Song LN Huang Y Cho S Simons SS Jr Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Mol Endocrinol (18): 1376-95, 2004. [Full Text/Abstract]
Wang Q Anzick S Richter WF Meltzer P Simons SS Jr Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors. J Steroid Biochem Mol Biol (91): 197-210, 2004. [Full Text/Abstract]
Chen J Blackford JA Jr Simons SS Jr PCR expression mutagenesis: a high-throughput mutation assay applied to the glucocorticoid receptor ligand-binding domain. Biochem Biophys Res Commun (321): 893-9, 2004. [Full Text/Abstract]
Chen J He Y Simons SS Jr Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. Biochemistry (43): 245-55, 2004. [Full Text/Abstract]
Chen S Simons SS Jr A second pathway for modulating glucocorticoid receptor transactivation properties. Mol Cell Endocrinol (199): 129-42, 2003. [Full Text/Abstract]
Webster JI Tonelli LH Moayeri M Simons SS Jr Leppla SH Sternberg EM Anthrax lethal factor represses glucocorticoid and progesterone receptor activity. Proc Natl Acad Sci U S A (100): 5706-11, 2003. [Full Text/Abstract]
Anzick SL Azorsa DO Simons SS Jr Meltzer PS Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1. BMC Cancer (3): 22, 2003. [Full Text/Abstract]
Simons SS Jr The importance of being varied in steroid receptor transactivation. Trends Pharmacol. Sci.(24): 253-259, 2003.
Murphy PJ Morishima Y Chen H Galigniana MD Mansfield JF Simons SS Jr Pratt WB Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. J Biol Chem (278): 34764-73, 2003. [Full Text/Abstract]
He Y Szapary D Simons SS Jr Modulation of induction properties of glucocorticoid receptor-agonist and -antagonist complexes by coactivators involves binding to receptors but is independent of ability of coactivators to augment transactivation. J Biol Chem (277): 49256-66, 2002. [Full Text/Abstract]
Kaul S Murphy PJ Chen J Brown L Pratt WB Simons SS Jr Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain. J Biol Chem (277): 36223-32, 2002. [Full Text/Abstract]
Chen J Kaul S Simons SS Jr Structure/activity elements of the multifunctional protein, GMEB-1. Characterization of domains relevant for the modulation of glucocorticoid receptor transactivation properties. J Biol Chem (277): 22053-62, 2002. [Full Text/Abstract]
Kaul S Blackford JA Jr Cho S Simons SS Jr Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. J Biol Chem (277): 12541-9, 2002. [Full Text/Abstract]
Zeng H Kaul S Simons SS Jr Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. Nucleic Acids Res (28): 1819-29, 2000. [Full Text/Abstract]