Inclusion Criteria:

1. HIV-1 infected males or females at least 18 years of age.
2. Three-class (NRTI, NNRTI, and PI) treatment-experienced (a minimum of 3-months duration for each class) with resistance to more than one PI (on the screening resistance testing).
3. CD4+ T lymphocyte count more than 50 cells/micro l and HIV 1 VL more than 1000 copies/mL at screening.
4. Patients must have at least one of the following permutations of active ARV medications available and must be willing to use them in the OBR for trial inclusion.
5. Chronic hepatitis C Virus infection demonstrated by HCV-RNA positivity or, Chronic hepatitis B infection demonstrated by anti HBc IgG Antibody and HB Surface Antigen positivity.
6. Acceptable screening laboratory values that indicate adequate baseline organ function.
7. ALT and AST <DAIDS Grade 3.
8. Acceptable medical history, as assessed by the investigator.
9. Only the four AIDS defining events listed below are acceptable as long as the event has been cured for at least 2 weeks before screening (Visit 1). Patients with history of other AIDS defining events are not allowed into the trial. The acceptable prior AIDS defining events include: Candidiasis (bronchi, trachea, lungs, esophageal), Herpes simplex: chronic ulcer(s) (more than 1 months duration), bronchitis, pneumonitis, or esophagitis, Mycobacterium tuberculosis (pulmonary or extrapulmonary), Pneumonia including Pneumocystis jiroveci (formerly carinii) pneumonia.
10. A reliable method of barrier contraception will be used by all female patients who are of reproductive potential, for at least three months prior to Visit 3, during the trial, and 30 days after completion or termination from the trial.

Exclusion Criteria:

1. Prior tipranavir use.
2. Known hypersensitivity to any of the ingredients to the tipranavir or ritonavir formulations.
3. ARV medication naive.
4. Genotypic resistance to TPV (defined as a TPV mutation score of more than 7).
5. Patients on recent drug holiday, defined as off ARV medications for at least 7 consecutive days within the month prior to screening.
6. Decompensated liver disease, including presence or history of ascites, variceal bleeding, or hepatic encephalopathy or having ever been diagnosed as having hepatic insufficiency of Child Pugh class B or C.

7. Female patients of childbearing potential who:

   • have a positive serum pregnancy test at screening or during the study,
   • are breast feeding,
   • are planning to become pregnant,
   • are not willing to use a barrier method of contraception, or
   • are only willing to use an estrogen-containing medication, e.g., ethinyl estradiol, as a method of contraception.
   • Use of investigational medications within 30 days before study entry or during the trial except for those investigationnal ARV drugs permitted during the trial as stated in inclusion criteria 6.
   • Use of concomitant drugs that may significantly reduce plasma levels of the study medications.
   • Use of immunomodulatory drugs or antineoplastic agents within 30 days before study entry or during the trial.
   • Inability to adhere to the requirements of the protocol, including active substance abuse, as defined by the investigator.
   • Anticipated need for an interferon-based regimen in the 48 weeks following the study entry.
   • Any other or additional plausible cause for chronic liver disease, including the presence of other viruses known or suspected to cause hepatitis.
   • Any active infection or neoplasm currently being treated.