Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.

This study is currently recruiting participants.

Verified by Instituto Valenciano de Infertilidad, Spain, March 2007

Sponsored by:	Instituto Valenciano de Infertilidad, Spain
Information provided by:	Instituto Valenciano de Infertilidad, Spain
ClinicalTrials.gov Identifier:	NCT00447395

Purpose

In recurrent miscarriage, the male factor has been poorly evaluated. In fact, in the vast majority of clinical protocols of recurrent miscarriage, the sperm is not considered or assessed. Recently, some studies have suggested the presence of genetic and metabolic sperm anomalies in couples suffering from repeated miscarriages. Specifically, DNA fragmentation and altered oxidative stress in the sperm and Y microdeletions from blood samples have been related to an increased risk of miscarriage.The aim of the present study is to compare these three parameters in: couples with recurrent miscarriage; oligozoospermic men with or without recurrent miscarriages; and healthy sperm donors, in order to determine their actual impact on this reproductive problem.

Condition
Recurrent Miscarriage

MedlinePlus related topics: Pregnancy Loss

U.S. FDA Resources

Study Type:	Observational
Study Design:	Longitudinal, Defined Population, Prospective Study
Official Title:	Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Male

Criteria

Inclusion Criteria:

4 groups

Recurrent miscarriage, <40 year-old-men, < 38 year-old-women, normal or mild affected sperm, normal parents karyotype, no thrombophilia, normal uterus, no endocrinopathy
The same criteria than in group A, but oligozoospermia (1-5 mill/ml)
Oligozoospermia (1-5 mill/ml), < 40 year-old-men, no recurrent miscarriages
Healthy young sperm donors

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00447395

Contacts

Contact: Jose Bellver, MD

(34) 96 3050900

jbellver@ivi.es

Locations

Spain
Ivi Valencia	Recruiting
VALENCIA, Spain, 46015

Sponsors and Collaborators

Instituto Valenciano de Infertilidad, Spain

Investigators

Principal Investigator:

Jose Bellver, MD

IVI Valencia

More Information

Study ID Numbers:	VLC-JB-1106-307-4
Study First Received:	March 13, 2007
Last Updated:	March 13, 2007
ClinicalTrials.gov Identifier:	NCT00447395
Health Authority:	Spain: Comité Ético de Investigación Clínica

Study placed in the following topic categories:

Pregnancy Complications
Abortion, Habitual
Stress
Spastic paraplegia epilepsy mental retardation

Abortion, Spontaneous
Congenital Abnormalities
Recurrence

Additional relevant MeSH terms:

Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on January 16, 2009