Study of the Natural Variation in Strokevolume - Full Text View

Sponsored by:	Rigshospitalet, Denmark
Information provided by:	Rigshospitalet, Denmark
ClinicalTrials.gov Identifier:	NCT00447200

Purpose

We would like to investigate the natural variation in the strokevolume of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in strokevolume, after a fluid bolus of 200ml Voluven, when using Esophageal Doppler.

Condition	Intervention
Stroke Volume Variation	Procedure: Esophagus Doppler monitoring Procedure: Fluid optimization

MedlinePlus related topics: Esophagus Disorders

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Study of the Natural Variation in Strokevolume, and Investigation in the Number of Cycles Necessary to Find a 10% Strokevolume Variation Using Esophageal Doppler

Further study details as provided by Rigshospitalet, Denmark:

Primary Outcome Measures:

Strokevolume variation before fluid optimization
Strokevolume variation after fluid optimization
Number of cycles needed in order to detect a 10% strokevolume increase after fluid bolus of 200ml Voluven.

Enrollment:	20
Study Start Date:	March 2007
Study Completion Date:	August 2007

Detailed Description:

We would like to investigate the natural variation in the strokevolume(SV) of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in SV, after a fluid bolus of 200ml Voluven, when using Esophageal Doppler.

Also we will compare the variation in SV both before and after the patients have been fluid optimized, using an algorithm of 10% increase in SV in order to receive another fluid bolus. The equipment used, will be the CardioQ from Deltex medical.

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Planned abdominal surgery

Exclusion Criteria:

Oesophageal pathology,
Age >90 yr or <18 yr,
Alcohol abuse,
Aneurism in thoracic aorta

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00447200

Locations

Denmark, Seeland
Rigshospitalet
Copenhagen, Seeland, Denmark, 2200

Sponsors and Collaborators

Rigshospitalet, Denmark

Investigators

Principal Investigator:

Christoffer Jorgensen, M.S

Dept of anesthesia 2041, ABD centre, Rigshospitalet, Blegdamsvej

More Information

Study ID Numbers:	Validation of cycles
Study First Received:	March 13, 2007
Last Updated:	October 12, 2007
ClinicalTrials.gov Identifier:	NCT00447200
Health Authority:	Denmark: National Board of Health

Keywords provided by Rigshospitalet, Denmark:

Stroke volume
SV variation
Esophagus Doppler
Goal Directed Therapy

Study placed in the following topic categories:

Esophageal disorder
Cerebral Infarction
Stroke
Esophageal Diseases

ClinicalTrials.gov processed this record on January 16, 2009