Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Melbourne Health |
---|---|
Information provided by: | Melbourne Health |
ClinicalTrials.gov Identifier: | NCT00446212 |
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.
Condition | Intervention | Phase |
---|---|---|
Anaesthesia Dreaming |
Drug: Propofol Drug: desflurane |
Phase IV |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Double-Blind, Active Control, Parallel Assignment, Pharmacodynamics Study |
Official Title: | Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane |
Estimated Enrollment: | 300 |
Study Start Date: | August 2006 |
Estimated Study Completion Date: | August 2007 |
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Kate Leslie, MD | 61-3-93427000 | kate.leslie@mh.org.au |
Australia, Victoria | |
Royal Melbourne Hospital | Recruiting |
Parkville, Victoria, Australia, 3050 | |
Contact: Kate Leslie, MD 61-3-93427000 kate.leslie@mh.org.au | |
Principal Investigator: Kate Leslie, MD | |
Australia, Western Australia | |
Royal Perth Hospital | Recruiting |
Perth, Western Australia, Australia, 6000 | |
Contact: Michael Paech, MD 61-8-9340 2222 michael. paech@health.wa.gov.au | |
Principal Investigator: Michael Paech, MD | |
King Edward Memorial Hospital for Women | Recruiting |
Subiaco, Western Australia, Australia, 6008 | |
Contact: Michael Paech, MD 61-8-9340 2222 michael.paech@health.wa.gov.au | |
Principal Investigator: Michael Paech, MD | |
New Zealand | |
Waikato Hospital | Recruiting |
Hamilton, New Zealand | |
Contact: Jamie Sleigh, MD 64-7-8398899 sleighj@waikatodhb.govt.nz | |
Principal Investigator: Michael Paech, MD |
Principal Investigator: | Kate Leslie, MD | Melbourne Health |
Study ID Numbers: | 2006.125 |
Study First Received: | March 8, 2007 |
Last Updated: | March 8, 2007 |
ClinicalTrials.gov Identifier: | NCT00446212 |
Health Authority: | Australia: Department of Health and Ageing Therapeutic Goods Administration |
anaesthesia propofol desflurane dreaming electroencephalography |
Desflurane Propofol |
Anesthetics, Intravenous Anesthetics, Inhalation Anesthetics, General Therapeutic Uses Hypnotics and Sedatives |
Physiological Effects of Drugs Central Nervous System Depressants Anesthetics Central Nervous System Agents Pharmacologic Actions |