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| Michael J. Iadarola, Ph.D., Investigator |
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Dr. Iadarola received his B.S. degree in Biology from American University, Washington, DC in 1973. In 1980, he received his Ph.D. in Pharmacology from Georgetown University where he worked with Dr. Karen Gale on the mechanisms of epilepsy and seizure control through the inhibitory amino acid transmiter GABA. Epilepsy research was continued in the in vitro hippocampal slice using electrophysiological methods at Duke University with Dr. W.A. Wilson. Dr. Iadarola obtained a Pharmacology Research Associate Trainee fellowship with the NIGMS in 1982 and worked at the NIMH with Drs. E. Costa and H.-Y. T. Yang on the molecular regulation of opioid neuropeptides. There he discovered that persistent pain up-regulated dynorphin opioid gene expression in the pain processing laminae of the spinal cord dorsal horn. Dr. Iadarola joined NIDCR in 1996 as chief of the Neuronal Gene Expression Unit. His laboratory studies the molecular biology of pain and pain control systems mainly in the dorsal root ganglion and the first synaptic connection in the spinal cord.
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Research Interests:
The laboratory investigates (a) synaptic plasticity in the dorsal spinal cord using subtraction cloning and differential expression profiling, (b) the molecular function of pain-transducing molecules in peripheral nerve endings, in particular the vanilloid receptor (VR1), and (c) new treatment strategies for the control of severe intractable pain. The novel approaches to pain control include selective pain cell deletion, pre-emptive analgesia, protein therapeutics and the use of viral vectors for in vivo gene transfer and expression of therapeutic bio-molecules. The research program integrates molecular, cellular, preclinical animal research and human clinical studies.
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Selected Recent Publications:
Yang HY Iadarola MJ (2003) Activation of spinal neuropeptide FF and the neuropeptide FF receptor 2 during inflammatory hyperalgesia in rats., Neuroscience 118, 179-87.
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Mannes AJ Martin BM Yang HY Keller JM Lewin S Gaiser RR Iadarola MJ (2003) Cystatin C as a cerebrospinal fluid biomarker for pain in humans., Pain 102, 251-256.
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Sarntinoranont M Iadarola MJ Morrison PF (2003) A kinetic analysis of substance P trafficking., J Pharm Sci 92, 232-43.
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Mannes AJ Cimino Brown D Perkowski SZ Keller J Caudle RM Iadarola MJ Meng QC (2002) Measurement of resiniferatoxin in cerebrospinal fluid by high-performance liquid chromatography., J Chromatogr B Analyt Technol Biomed Life Sci 780, 475-9.
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Rosier EM Iadarola MJ Coghill RC (2002) Reproducibility of pain measurement and pain perception., Pain 98, 205-16.
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Contact Information:
Dr. Michael J. Iadarola
Neuronal Gene Expression Unit
Pain and Neurosensory Mechanisms Branch, NIDCR
Building 49, Room 1A11
49 Convent Drive, MSC 4410
Bethesda, MD 20892-4410
Telephone: (301) 496-2758 (office),
(301) 496-2758 (laboratory),
(301) 402-0667 (fax)
Email: miadarola@dir.nidcr.nih.gov
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