Funding Announcements Percussion Rhythmyx braininfo@ninds.nih.gov Copyright 2008, National Institute of Neurological Disorders and Stroke Saturday Sunday http://blogs.law.harvard.edu/tech/rss http://www.ninds.nih.gov/funding/funding_announcements/allcurrent.htm purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and “protected time” (three, four, or five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. The goal of the NINDS K01 is to diversify the pool of independent neuroscience research investigators. The NINDS recognizes the unique and compelling need to promote diversity in participation in neuroscience research and expects these efforts to diversify the neuroscience research workforce to lead to the recruitment of the most talented researchers from all groups. Prospective applicants are encouraged to contact NINDS staff for programmatic and budgetary information. http://www.ninds.nih.gov/funding/funding_announcements/pa/PAR-09-065.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PAR-09-065.htm The aim of this FOA issued by the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the National Institute on Drug Abuse (NIDA) is to facilitate the discovery of new small molecule probes for investigating biological function in the nervous system by providing funding for advanced medicinal chemistry and the biological testing of compounds. Eligible Investigators will have identified probe candidates via screening of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and be able to show that the structural features of these small molecules are related to their biological activity. Project proposals should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the investigator. Applicants are strongly encouraged to utilize publicly available cheminformatic capabilities for the acquisition of compounds, and semi-custom synthesis of analogues, which is required of these studies. http://www.ninds.nih.gov/funding/funding_announcements/rfa/RFA-NS-09-003.htm http://www.ninds.nih.gov/funding/funding_announcements/rfa/RFA-NS-09-003.htm The purpose of this notice is to announce that the NINDS is seeking experienced medicinal chemists to provide small molecule design support to investigators applying to the Research Funding Announcement NS-09-003, entitled; “Optimization of Small Molecule Probes for the Nervous System” (R21). It is expected that medicinal chemistry planning will be included as part of a successful project proposal. Chemistry expertise will be needed to help design and evaluate small molecule analogues in support of structure-activity relationship studies and compound optimization. NINDS, and other NIH Institutes participating in the Program (NIAAA, NIDA), acknowledge the importance of having medicinal chemistry input to the small molecule design and optimization required of this Program, and will therefore support funding allowance within proposals responding to RFA-NS-09-003 for attaining such expertise. Applicants to this Program that do not presently have access to such a resource will be able to choose from a listing that will be provided upon request by the Program Director, of qualified medicinal chemists that are willing to provide support as an active participant in the proposed studies. As it is expected that compound acquisition in this Program will be substantially guided by external procurement using available cheminformatic tools the consultant services described in this notice will not require the provision of chemical synthesis support. http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-004.htm http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-004.htm The National Institute of Neurological Disorders and Stroke (NINDS) announces the availability of one-year administrative supplements for NINDS-funded grantees to stimulate new interdisciplinary collaborations in translational research. The proposed studies must be within the scope of the peer-reviewed activities specified within the NINDS parent award and collaborators may not have a significant history of joint interactions. http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-005.htm http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-005.htm The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue translational and pilot clinical studies for neural prosthetics. The program will utilize the cooperative agreement mechanism to enable support for milestone-driven projects for the design, development, and demonstration of clinically-useful neural prosthetic devices. Activities supported in this program include implementation of clinical prototype devices, preclinical safety and efficacy testing, design verification and validation activities, pursuit of regulatory approval for clinical study, and proof-of-concept or pilot clinical studies. http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-063.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-063.htm This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to pursue translational and pilot clinical studies for neural prosthetics. The program will utilize the cooperative agreement mechanism to enable support for milestone-driven projects for the design, development, and demonstration of clinically-useful neural prosthetic devices. Activities supported in this program include implementation of clinical prototype devices, preclinical safety and efficacy testing, design verification and validation activities, pursuit of regulatory approval for clinical study, and proof-of-concept or pilot clinical studies. http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-064.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-064.htm This funding opportunity announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications that propose research and development of probes useful in imaging the structure and function of the brain and other parts of the nervous system, with award duration and amounts greater than those routinely allowed under the SBIR programs. Specifically this FOA invites SBIR applications that propose research and development of probes that generate signals detectable by one or more imaging modality. Such probes should indicate the structure or function of molecules or subcellular elements of neurons or other cells of the nervous system. Of special interest are applications that propose research and development of novel probes, although significant enhancements of already existing probes are also invited. Grant applications may propose projects that will result in probes solely intended for use in research or probes that might have clinical utility. It is expected that this initiative will require expertise from a variety of disciplines, including neuroscience, biology, chemistry, physics, engineering, biotechnology, and bioengineering. Moreover, it is anticipated that these types of expertise will be brought together in various combinations in individual proposed projects. http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-062.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-062.htm Under this Funding Opportunity Announcement (FOA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), National Institute of Mental Health (NIMH), and the National Institute of Nursing Research (NINR) invite research grant applications that address the underlying neurobiological mechanisms associated with cognitive impairment and mood disturbance in Parkinson's disease (PD), that address the development of clinical interventions and therapeutics for cognitive impairment and affective symptoms in PD, or that promote improved clinical diagnosis or treatment of cognitive and affective impairment in PD. A goal of this FOA is to begin a process where basic and clinical scientists from various disciplines can overcome barriers to cross-disciplinary and biobehavioral research and examine all aspects of cognition and affective regulation in the context of the diagnosis and treatment of Parkinson's disease. http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-033.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-033.htm Under this Funding Opportunity Announcement (FOA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Mental Health (NIMH) invite research grant applications to develop new, or improve existing, animal models which address the underlying neurobiological mechanisms associated with cognitive impairment and mood disturbance in Parkinson's disease (PD), that assist in the development of clinical interventions and therapeutics for cognitive impairment and affective symptoms in PD, or that promote improved treatment of cognitive and affective impairment in PD. A goal of this FOA is to begin a process where basic and clinical scientists from various disciplines can overcome barriers to cross-disciplinary and biobehavioral research and examine all aspects of cognition and affective regulation in the context of the diagnosis and treatment of Parkinson's disease. http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-034.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PA-09-034.htm The NINDS gives notice of the extension of the expiration date for (PAR-07-294), PRELIMINARY INVESTIGATIONS LEADING TO OPTIMAL TRIALS IN NEUROLOGY (R01), until January 8, 2010. http://grants.nih.gov/grants/guide/pa-files/PAR-07-294.html http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-001.htm http://www.ninds.nih.gov/funding/funding_announcements/notice/NOT-NS-09-001.htm This FOA is issued by the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. This FOA is a follow up of a previous Roadmap RFA (RM-04-021 “Innovation in Molecular Imaging Probes”). The purpose of this initiative is to encourage the development of novel molecular imaging approaches that can detect and image specific molecular activities in vivo, and have the potential for clinical applications. Novel molecular imaging approaches developed through this initiative can focus on one (or both) of the following long-term translational goals: (1) imaging the characteristic markers, and function, of normal cells in control human subjects and patients, and (2) imaging the characteristic markers, and biochemical or physiological abnormalities, of disease cells in patients. Potential abnormalities that could provide early markers for disease include (but are not restricted to): inflammation, fibrosis, immune cell activation, altered signal transduction pathways, altered gene expression pathways, and altered post-translational modification of proteins. This initiative solicits applications that explore innovative “high-impact” approaches, rather than incremental technology development that is already supported by current NIH programs. http://www.ninds.nih.gov/funding/funding_announcements/pa/PAR-09-016.htm http://www.ninds.nih.gov/funding/funding_announcements/pa/PAR-09-016.htm