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| Sponsors and Collaborators: |
Albany Medical College Department of Defense |
|---|---|
| Information provided by: | Albany Medical College |
| ClinicalTrials.gov Identifier: | NCT00249080 |
Purpose
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis are recognized as a major health concern at the present time. There is information in magnetic resonance imaging (MRI) studies regarding the role of brain iron in normal brain aging that may be enhanced with the use of better scanning equipment and procedures, and by correlating this information with clinical data. This research study aims to develop and evaluate a number of techniques that can potentially improve the effectiveness of three tesla (3T) magnetic resonance imaging of neurodegenerative brain disorders.
| Condition |
|---|
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Neurodegenerative Diseases Mild Cognitive Impairment |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | High Field MRI of Brain Iron in Neurodegenerative Disease |
| Enrollment: | 182 |
| Study Start Date: | June 2005 |
| Study Completion Date: | August 2007 |
Eligibility: A healthy person without memory complaints or someone with neurodegenerative disease. However, the person should not have metal in the body (ie, pacemaker, implants, shrapnel, etc.), should not be pregnant, and should not have claustrophobic anxieties.
Study Procedures: During a regular office visit, a neurologist will perform a routine physical and neurological examination, including your medical and family history, to determine your eligibility for this study. You will then be scheduled for a series of neuropsychological tests, which take between 1 to 1.5 hours, and an MRI scan, which takes approximately 1 hour to complete. This is a longitudinal study and you may be asked to repeat these procedures approximately every six months for the duration of this 2 year project.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Approximately equal numbers of subjects with clinically diagnosed Alzheimer's disease, multiple sclerosis, Parkinson's disease and normal controls (age and gender matched).
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Study Director: | Earl A Zimmerman, MD | Albany Medical College |
| Principal Investigator: | John F Schenck, MD, PhD | GE Global Research Center & Neurosciences Advanced Imaging Research Center |
More Information
| Responsible Party: | Albany Medical College ( John Schenck, MD PhD; Principal Investigator ) |
| Study ID Numbers: | AMC-IRB-1599, A-13214 |
| Study First Received: | November 3, 2005 |
| Last Updated: | September 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00249080 |
| Health Authority: | United States: Institutional Review Board |
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3T MRI neurodegenerative disease Alzheimer's disease spectroscopy |
Normal, healthy subject without memory complaint Not pregnant MR compatible |
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Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Healthy Dementia |
Neurodegenerative Diseases Iron Cognition Disorders Delirium |
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Nervous System Diseases |
