| Agent Name |
Chlorobenzene |
|---|
| Alternative Name |
Monochlorobenzene |
|---|
| CAS Number |
108-90-7 |
|---|
| Formula |
C6-H5-Cl |
|---|
| Major Category |
Solvents |
|---|
| Synonyms |
Benzene chloride; Chlorobenzol; MCB; Phenyl chloride; Monochlorobenzene; [NIOSH] UN1134 |
|---|
| Category |
Chlorinated Aromatic |
|---|
| Description |
Colorless liquid with an almond-like odor; [NIOSH] |
|---|
| Sources/Uses |
Used as a solvent for paints, adhesives, polishes, waxes, and natural rubber; used as a dry cleaning agent and an intermediate in the synthesis of organic chemicals; [NIOSH Guidelines for Chemical Hazards] |
|---|
| Comments |
Odor threshold = 0.21 ppm; repeated or prolonged skin contact can cause burns; [NIOSH Guidelines for Chemical Hazards] In animal studies, high doses are toxic to the liver. [ACGIH] If left on clothes, can cause reddening of skin; [CHRIS] |
|---|
| Exposure Assessment |
|---|
| BEI |
Total 4-chlorocatechol in urine = 100 mg/g creatinine at end of shift at end of workweek; Total p-chlorophenol in urine = 20 mg/g creatinine at end of shift at end of workweek; |
|---|
| Skin Designation (ACGIH) |
No |
|---|
| TLV (ACGIH) |
10 ppm |
|---|
| PEL (OSHA) |
75 ppm |
|---|
| MAK |
10 ppm |
|---|
| IDLH (NIOSH) |
1000 ppm |
|---|
| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: AIHA [1964] reported that 8,000 ppm was fatal to cats in 30 minutes [Patty 1963; Flury and Zernik 1931]. Patty [1963] reported that the exposure of cats for 1 hour to 2,400 to 2,900 ppm causes unsteadiness, tremor, and twitching [Flury and Zernik 1931]. Based on the data cited above, an IDLH of 2,400 ppm is chosen for this draft technical standard. . . . Basis for revised IDLH: The revised IDLH for chlorobenzene is 1,000 ppm based on acute inhalation toxicity data in animals [DeCeaurriz et al. 1981; Flury and Zernik 1931]. |
|---|
| Vapor Pressure |
12 mm Hg |
|---|
| Odor Threshold Low |
0.08 ppm |
|---|
| Odor Threshold High |
5.9 ppm |
|---|
| RD50 |
1054 ppm |
|---|
| Lethal Concentration |
LC50 (rats) = 2,965 ppm |
|---|
| Explanatory Notes |
Detection odor threshold from AIHA (mean = 1.3 ppm); Flash point = 29.2 deg C; |
|---|
| Half Life |
Estimated from animal studies: 2 days; [TDR, p. 313] |
|---|
| Reference Link |
ATSDR ToxFAQs - Chlorobenzene |
|---|
| Flammability (NFPA) |
3: may ignite at ambient temperature |
|---|
| Adverse Effects |
|---|
| Dermatotoxin |
Skin Burns |
|---|
| Neurotoxin |
CNS Solvent Syndrome |
|---|
| Hepatotoxin |
Hepatotoxin, Secondary |
|---|
| Links to Other NLM Databases |
|---|
| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CHLOROBENZENE
|
|---|
