| Agent Name |
2-Butoxyethanol |
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| Alternative Name |
Ethylene glycol monobutyl ether |
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| CAS Number |
111-76-2 |
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| Formula |
C6-H14-O2 |
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| Major Category |
Solvents |
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| Synonyms |
2-Butoxy-1-ethanol; 2-; 2-Butoxyethanol; 3-Oxa-1-heptanol; BUCS; Butoxyethanol; Butyl cellosolve; Butyl cellu-sol; Butyl glycol; Butyl oxitol; Chimec NR; Dowanol EB; EGBE; EGMBE; Ektasolve EB; Ethanol, 2-butoxy-; Ethylene glycol butyl ether; Ethylene glycol n-butyl ether; Ethylene glycol, monobutyl ether; Gafcol EB; Glycol butyl ether; Glycol ether EB; Glycol monobutyl ether; Jeffersol EB; Monobutyl ether of ethylene glycol; Monobutyl ethylene glycol ether; O-Butyl ethylene glycol; Poly-Solv EB; n-Butoxyethanol; [ChemIDplus] UN2369 |
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| Category |
Glycol Ethers |
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| Description |
Colorless liquid with a mild, ether-like odor; [NIOSH] |
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| Sources/Uses |
Used as solvent in surface coatings; [ACGIH] Also used in hydraulic fluids, glass cleaners, and leather cleaners; [Sullivan, p. 1203] |
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| Comments |
Severe hemoglobinuria and changes in the lungs, kidneys, and liver are seen in mice after 7-hour lethal concentration studies. Volunteers showed no evidence of adverse effects other than mucous membrane irritation after 8 hour exposures to 200 ppm. No increase in red cell fragility was seen after these brief exposures. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Humans are less susceptible than animals to red blood cell hemolysis. [Sullivan, p. 1204] See "Glycol ethers." |
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| Reference Link |
ATSDR ToxFAQs - 2-Butoxyethanol |
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| Exposure Assessment |
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| BEI |
Butoxyacetic acid (BAA) in urine = 200 mg/g creatinine at end of shift. |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
20 ppm |
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| PEL (OSHA) |
50 ppm |
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| MAK |
20 ppm |
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| IDLH (NIOSH) |
700 ppm |
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| Excerpts from Documentation for IDLHs |
Human data: It has been stated that humans would be able to tolerate saturated concentrations (i.e., about 1,000 ppm) for 1 hour without experiencing any significant nonreversible effects [Carpenter et al. 1956]. |
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| Vapor Pressure |
0.8 mm Hg |
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| Odor Threshold Low |
0.1 ppm |
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| Odor Threshold High |
0.35 ppm |
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| RD50 |
2824 ppm |
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| Lethal Concentration |
LC50 (rats)= 450 ppm/4hr; |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.1 ppm); Flash point = 62 deg C; |
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| Half Life |
0.6 to 4.8 hours [Sullivan, p. 1203] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ETHYLENE GLYCOL MONO-N-BUTYL ETHER
|
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