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Genetic Investigation of ANthropometric Traits Consortium.
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
PMID: 19079261 [PubMed - indexed for MEDLINE]
PMCID: PMC2695662
Nat Genet. 2009 Jan; 41(1):18-24. Epub 2008 Dec 14.
[Nat Genet. 2009]
Nat Genet. 2008 Jun; 40(6):768-75. Epub 2008 May 4.
[Nat Genet. 2008]
PLoS Genet. 2007 Jul; 3(7):e115.
[PLoS Genet. 2007]
Int J Obes (Lond). 2007 May; 31(5):829-41. Epub 2006 Oct 24.
[Int J Obes (Lond). 2007]
Nat Clin Pract Endocrinol Metab. 2008 Mar; 4(3):156-63. Epub 2008 Jan 15.
[Nat Clin Pract Endocrinol Metab. 2008]
Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, et al. PLoS Genet. 2009 Jun; 5(6):e1000539. Epub 2009 Jun 26.
[PLoS Genet. 2009]
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, et al. PLoS Genet. 2009 Jun; 5(6):e1000508. Epub 2009 Jun 26.
Kilpeläinen TO, Bingham SA, Khaw KT, Wareham NJ, Loos RJ. Hum Mol Genet. 2009 Sep 15; 18(18):3496-501. Epub 2009 Jun 15.
[Hum Mol Genet. 2009]
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