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Nat Genet. 2008 Nov;40(11):1270-1.
Male-pattern baldness susceptibility locus at 20p11.
Richards JB,
Yuan X,
Geller F,
Waterworth D,
Bataille V,
Glass D,
Song K,
Waeber G,
Vollenweider P,
Aben KK,
Kiemeney LA,
Walters B,
Soranzo N,
Thorsteinsdottir U,
Kong A,
Rafnar T,
Deloukas P,
Sulem P,
Stefansson H,
Stefansson K,
Spector TD,
Mooser V.
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
PMID: 18849991 [PubMed - indexed for MEDLINE]
PMCID: PMC2672151