A polygenic model with common variants may predict lung adenocarcinoma risk in humans.
Galvan A,
Falvella FS,
Spinola M,
Frullanti E,
Leoni VP,
Noci S,
Alonso MR,
Zolin A,
Spada E,
Milani S,
Pastorino U,
Incarbone M,
Santambrogio L,
Neira AG,
Dragani TA.
Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. (c) 2008 Wiley-Liss, Inc.
PMID: 18729187 [PubMed - indexed for MEDLINE]