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Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
PMID: 18711365 [PubMed - indexed for MEDLINE]
PMCID: PMC2703780
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[Behav Brain Funct. 2009]
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[Dis Model Mech. 2009]
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