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Sponsors and Collaborators: |
University of Heidelberg Else Kröner Fresenius Foundation |
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Information provided by: | University of Heidelberg |
ClinicalTrials.gov Identifier: | NCT00463333 |
Summary:
Postoperative delirium is a highly prevalent disease (10–30% prevalence) after surgery in intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the present project is to investigate risk factors for postoperative delirium in more detail, to evaluate respective cognitive test systems and to measure EEG activity parallel to patients’ serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium. Because delirium is also associated with higher postoperative mortality and morbidity, with delayed functional recovery, and postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem.
Condition |
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Postoperative Delirium |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Germany | |
Intensive Care Unit, Clinic of Anesthesiology | |
Heidelberg, Germany, 69120 |
Principal Investigator: | Markus A Weigand, PhD, MD | Medical Faculty, Clinic of Anesthesiology, University of Heidelberg |
Principal Investigator: | Konstanze Plaschke, Prof. | Clinic of Anesthesiology |
Study ID Numbers: | 196/2004 |
Study First Received: | September 10, 2005 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00463333 |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
postoperative delirium psychometric testing EEG serum markers |
Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Neurologic Manifestations Confusion |
Dementia Neurobehavioral Manifestations Cognition Disorders Delirium |
Nervous System Diseases |