• Center for Epidemiological Studies-Depression Scale (CES-D) [ Time Frame: baseline, 6 weeks, 6 months, 12 months post-disclosure ] [ Designated as safety issue: Yes ]
  
• Beck Anxiety Inventory (BAI) [ Time Frame: baseline, 6 weeks, 6 months, 12 months post-disclosure ] [ Designated as safety issue: Yes ]
  

• Impact of Events Scale (IES) [ Time Frame: 6 weeks, 6 months, 12 months post-disclosure ] [ Designated as safety issue: No ]
  
• Future Attitudes Scale (FAS) [ Time Frame: baseline, 6 weeks, 6 months, 12 months post-disclosure ] [ Designated as safety issue: No ]
  
• Positive and Negative Affect Schedule (PANAS) [ Time Frame: baseline, 6 weeks, 6 months, 12 months post-disclosure ] [ Designated as safety issue: No ]
  

Alzheimer's disease is a common condition affecting memory and thinking. Genes can sometimes be used to provide risk estimates for the eventual development of certain common diseases. Apolipoprotein E (APOE) is one gene that has been identified which can provide information about a person's chances of developing Alzheimer's diseases. Previous research explored the behavioral and psychological impact of receiving genetic risk information for Alzheimer's disease (AD). The REVEAL I Study, funded in 1999, showed that an Alzheimer's disease genetic risk assessment can be given to relatives of people with AD in a safe way. REVEAL II, which was funded in 2003, demonstrated that this same information can be given in a condensed education and counseling protocol without causing severe psychological harm. REVEAL III will further study different ways of providing genetic risk information for Alzheimer's disease.

Participation in this study will entail an initial screening phone call to determine eligibility, followed by a phone interview which will ask about demographic information and thoughts and feelings about AD. Participants will complete a mailed survey. Following completion of the survey, a genetic counselor will meet with the participant at the clinic to review family and medical history, administer additional questionnaires asking about AD and genetic testing, and draw blood for genetic testing. Results will be disclosed either in person or over the phone about 3 to 4 weeks later. The genetic counselor will make a brief follow-up phone call 1 week after that. The participant will visit the clinic twice to provide additional information, at 6 weeks and 6 months after disclosure. Finally, the participant will complete a mailed 12 month survey, and the genetic counselor will make a brief follow-up phone call.