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Abstract

Title: IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis.
Author: Wilson WA, Morgan OC, Barton EN, Smikle M, Hanchard B, Blattner WA, Doggett S, Gharavi AE
Journal: Lupus 4(2):138-141
Year: 1995
Month: April

Abstract: A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies occur in about 26% of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-1 or other nontreponemal infections.