| Topic: | Diabetes (DM) |
| Title: | Vascular Abnormalities in the Prediabetic State. |
| Author: | Caballero, A.E., et al. |
| Source: | In: Johnstone, M.T. and Veves, A. Diabetes and Cardiovascular Disease. Totowa, NJ: The Humana Press, Inc. 2001. p. 65-80. |
| Availability: | Available from The Humana Press, Inc. 999 Riverview Dr., Suite 208 Totowa, NJ 07512. (973) 256-1699. Fax (973) 256-8341. E-mail: humana@humanapr.com PRICE: $125.00, plus shipping and handling. ISBN: 089603755X |
| Abstract: | With over ten million diagnosed patients and another five million undiagnosed, diabetes mellitus and its complications is a major public health problem that will assume epidemic proportions as the population grows older. This chapter on vascular abnormalities in the prediabetic state is from a textbook that offers physicians practical knowledge about cardiovascular disease and diabetes. This chapter is in Part I, which focuses on pathophysiology, including the mechanisms and risk factors for diabetic cardiovascular disease. The authors note that the risk for macrovascular (large blood vessel) disease (including coronary heart disease or CHD) in diabetes seems to depend to a considerable degree on other associated abnormalities such as hypertension (high blood pressure), dyslipidemia (altered levels of fats in the blood), altered fibrinolysis, and obesity, all components of the insulin resistance syndrome. Since the insulin resistance syndrome is usually present before the development of diabetes, a significant contribution to the risk for cardiovascular disease in people with diabetes is established before the appearance of hyperglycemia. The authors discuss the entity of prediabetes, cardiovascular risk and the prediabetic state, endothelial function (the cells lining body cavities and the cardiovascular system), vascular reactivity in type 2 diabetes and in the prediabetic state, endothelial activation, mechanisms involved in vascular abnormalities in the prediabetic state, and diabetes prevention. The authors briefly describe the Diabetes Prevention Program (DPP), a national research project aiming to prevent or slow the development of type 2 diabetes in individuals with impaired glucose tolerance (IGT). 2 figures. 3 tables. 109 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Diabetes Mellitus. Cardiovascular Diseases. Cardiovascular System. Patient Care Management. Cardiovascular Risk Factors. Complications. Metabolism. Hypertension. Hyperlipidemia. Insulin Resistance. Pathophysiology. |
| Minor Keywords: | Coronary Diseases. Symptoms. Diagnosis. Etiology. Obesity. Diabetic Angiopathy. Blood Lipids. Drug Therapy. Hyperinsulinism. Blood Pressure. Drug Effects. Prevention. |
| Publication Number: | DMBK10059 |
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