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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001975 |
Tuberous sclerosis is a rare, hereditary disease in which patients develop multiple tumors. Although not cancerous, the tumors can affect various organs, including the heart, lungs, kidneys, skin, and central nervous system, with serious medical consequences. The severity of disease varies greatly among patients, from barely detectable to fatal. This study will investigate what causes skin tumors to develop in patients with this disease.
Patients with tuberous sclerosis 18 years and older may enroll in this study. Participants will undergo a medical history and thorough skin examination by a dermatologist. Those with skin tumors will be asked to undergo biopsy (tissue removal) of up to eight lesions, under a local anesthetic, for research purposes. The biopsies will all be done the same day. The tissue samples will be used for: examination of genetic changes, measurement of certain proteins and other substances, and growing in culture to study the genetics of tuberous sclerosis.
Condition |
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Hereditary Neoplastic Syndrome Tuberous Sclerosis |
Study Type: | Observational |
Official Title: | Cutaneous Tumorigenesis in Patients With Tuberous Sclerosis |
Estimated Enrollment: | 130 |
Study Start Date: | January 2000 |
Patients with tuberous sclerosis develop benign cutaneous tumors that are typically multiple in number and location. These tumors include facial angiofibromas, forehead plaques, shagreen patches, periungual fibromas, and gingival fibromas. The tumors are permanent, slow growing, and often disfiguring. The purpose of this study is to elucidate the molecular basis for these tumors. Specifically, we plan to identify the genetically altered cells in these hamartomatous lesions, and to quantify factors (e.g. cytokines) produced by these cells which induce the growth of these tumors. To accomplish this, we plan to obtain samples of these cutaneous tumors, to test tumor DNA for loss of heterozygosity, and to measure RNA and protein expression levels.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients will be those already diagnosed with TSC based on clinical criteria and/or genetic testing.
The clinical features of TSC considered of major significance are: facial angiofibromas or forehead plaque, nontraumatic periungual fibromas, three or more hypomelanotic macules, shagreen patch, multiple retinal nodular hamartomas, cortical tuber, subependymal nodule, subependymal giant cell astrocytoma, cardiac rhabdomyoma, lymphangioleiomyomatosis, and renal angiomyolipoma.
The minor features of TSC are: multiple randomly distributed pits in dental enamel, hamartomatous rectal polyps, bone cysts, cerebral white matter radial migration lines, gingival fibromas, nonrenal hamartoma, retinal achromic patch, "confetti" skin lesions, and multiple renal cysts.
EXCLUSION CRITERIA:
Inability to give informed consent.
Tendency to keloid formation.
Allergy to anesthetics.
Bleeding abnormality.
Contact: Mary Haughey, R.N. | (301) 496-3632 | mhaughey@nhlbi.nih.gov |
United States, Maryland | |
United States Uniformed Health Service | Recruiting |
Bethesda, Maryland, United States, 20889 | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 000051, 00-H-0051 |
Study First Received: | January 20, 2000 |
Last Updated: | October 9, 2008 |
ClinicalTrials.gov Identifier: | NCT00001975 |
Health Authority: | United States: Federal Government |
Skin Biopsy Familial Tumor Syndrome Cell Growth |
Loss of Heterozygosity Cytokines Tuberous Sclerosis |
Nervous System Malformations Sclerosis Skin Neoplasms Neurodegenerative Diseases Bourneville syndrome Tuberous Sclerosis Neoplastic Syndromes, Hereditary |
Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Tuberous sclerosis Malformations of Cortical Development Congenital Abnormalities Neurocutaneous Syndromes |
Neoplasms Disease Pathologic Processes |
Syndrome Nervous System Diseases Hamartoma |