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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001776 |
Imaging studies of the brain have revealed the different areas involved in the processes of learning and reasoning. However, the specific role these regions play in these processes, or if stimulating these areas can improve these processes is unknown.
Researchers would like to use repetitive transcranial stimulation (rTMS) to better understand the roles of individual brain regions on the processes of learning and reasoning. Repetitive transcranial magnetic stimulation (rTMS) involves the placement of a cooled electromagnet with a figure-eight coil on the patient's scalp, and rapidly turning on and off the magnetic flux. This permits non-invasive, relatively localized stimulation of the surface of the brain (cerebral cortex). The effect of magnetic stimulation varies, depending upon the location, intensity and frequency of the magnetic pulses.
The purpose of this study is to use rTMS to help determine the roles of different brain regions in the development of implicit learning of motor sequences and analogic reasoning. In addition, researchers hope to evaluate if stimulation of these regions speeds up the process of learning or analogic reasoning.
Condition | Intervention |
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Cerebellar Disease Dementia Healthy Parkinson's Disease |
Device: Cadwell Rapid Rate Magnetic Stimulator |
Study Type: | Observational |
Official Title: | Can Stimulation of Frontal Cortical Regions Facilitate Performance on Tests of Procedural Implicit Learning and Analogical Reasoning? |
Estimated Enrollment: | 122 |
Study Start Date: | October 1997 |
Estimated Study Completion Date: | December 2003 |
The human frontal cortex subserves a number of psychological processes including those necessary for adequate implicit learning of visuomotor sequences and analogical reasoning.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA
Right handed normal volunteers (18-65 years old).
Patients with Parkinson's disease off medication.
Patients with cerebellar deficits.
Patients with frontal lobe lesions.
Patients with frontal lobe dementia.
EXCLUSION CRITERIA
Subjects with personal or family history of seizures or other neurological disorders.
Pregnant women.
Volunteers or patients with severe coronary artery disease.
Metal in the cranium except mouth.
Intracardiac lines.
Increased intracranial pressure as evaluated by clinical means.
Cardiac pacemakers.
Intake of neuroleptics.
Study ID Numbers: | 980025, 98-N-0025 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001776 |
Health Authority: | United States: Federal Government |
Magnetic Stimulation Plasticity SRTT Sequence Implicit Memory Explicit Memory |
Memory Parkinson's Disease Cerebellar Deficit Frontal Lobe Lesions Frontal Lobe Dementia Normal Volunteer |
Ganglion Cysts Basal Ganglia Diseases Central Nervous System Diseases Healthy Brain Diseases Neurodegenerative Diseases Cognition Disorders Delirium, Dementia, Amnestic, Cognitive Disorders |
Mental Disorders Parkinson Disease Movement Disorders Parkinsonian Disorders Dementia Cerebellar Diseases Delirium |
Nervous System Diseases |