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Collection of Blood and Bone Marrow From Normal Volunteers and Patients for Research Purposes
This study is ongoing, but not recruiting participants.
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00001627
  Purpose

This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production.

Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and normal volunteers.

These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions.


Condition
Aplastic Anemia
Fanconi's Anemia
Healthy
Hematologic Disease
Myelodysplastic Syndrome

MedlinePlus related topics: Anemia
U.S. FDA Resources
Study Type: Observational
Official Title: Collection of Blood and Bone Marrow From Normal Volunteers and Patients for Research Purposes

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 375
Study Start Date: June 1997
Detailed Description:

This protocol defines in general terms the purposes for which blood and bone marrow specimens will be collected by members of the Hematology Branch and the conditions under which the sampling will be performed. Samples of blood and bone marrow from normal volunteers and from patients are indispensable for many research projects, including studies of normal and abnormal hematopoiesis, the viral etiology of blood diseases, and the role of the immune system in marrow failure and related conditions.

  Eligibility

Ages Eligible for Study:   2 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

Normal volunteers age greater than or equal to 18 years.

Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).

EXCLUSION CRITERIA:

History of a significant bleeding disorder.

Abnormal host-defense mechanisms.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001627

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

NIH Clinical Center Detailed Web Page  This link exits the ClinicalTrials.gov site

Study ID Numbers: 970130, 97-H-0130
Study First Received: November 3, 1999
Last Updated: July 18, 2008
ClinicalTrials.gov Identifier: NCT00001627  
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Bone Marrow
Hematopoiesis
DNA
RNA
Viruses
Normal Volunteer
Aplastic Anemia
Myelodysplasia
Fanconi's Anemia
Single Lineage Cytopenia

Study placed in the following topic categories:
Myelodysplastic syndromes
Metabolic Diseases
Precancerous Conditions
Hematologic Diseases
Fanconi Anemia
Myelodysplasia
Myelodysplastic Syndromes
Anemia
Healthy
Virus Diseases
Preleukemia
Fanconi's anemia
Genetic Diseases, Inborn
Anemia, Aplastic
Metabolic disorder
Aplastic anemia
Bone Marrow Diseases

Additional relevant MeSH terms:
Neoplasms
Pathologic Processes
Disease
Anemia, Hypoplastic, Congenital
Syndrome
DNA Repair-Deficiency Disorders

ClinicalTrials.gov processed this record on January 15, 2009