Studies of Blood Flow to the Brain During Thought

This study is currently recruiting participants.

Verified by National Institutes of Health Clinical Center (CC), May 2008

Sponsored by:	National Institute of Mental Health (NIMH)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001360

Purpose

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.

This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.

Condition
Cognition Disorder Healthy

MedlinePlus related topics: MRI Scans Memory

U.S. FDA Resources

Study Type:	Observational
Official Title:	Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	1300
Study Start Date:	July 1993

Detailed Description:

Magnetic resonance imaging will be used to measure hemodynamic changes in healthy human subjects engaged in performing cognitive tasks. Specific questions concerning the location of the neural systems that mediate perceptual and semantic representations of objects and the spatial coordinate systems used for object localization will be addressed. The studies proposed here will be conducted only on normal adult men and women to examine the functional organization of the intact human brain.

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Normal adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.

EXCLUSION CRITERIA:

Subjects will be excluded if they have evidence of, or a history of, learning disability, psychiatric condition, head trauma, seizures or other neurological condition, alcoholism or substance abuse, hypertension, or cardiovascular disease.

We will also exclude subjects with vision and/or hearing problems severe enough to interfere with testing.

Females with a positive pregnancy test will be excluded from neuroimaging studies.

All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Those whose history is suggestive of such a problem will be excluded. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded because of possible risks during MRI scanning.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001360

Contacts

Contact: Patient Recruitment and Public Liaison Office	(800) 411-1222	prpl@mail.cc.nih.gov
Contact: TTY	1-866-411-1010

Locations

United States, Maryland
Johns Hopkins University	Recruiting
Baltimore, Maryland, United States, 21205
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

More Information

NIH Clinical Center Detailed Web Page This link exits the ClinicalTrials.gov site

Publications:

Andersen RA, Asanuma C, Essick G, Siegel RM. Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule. J Comp Neurol. 1990 Jun 1;296(1):65-113.

Baizer JS, Ungerleider LG, Desimone R. Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques. J Neurosci. 1991 Jan;11(1):168-90.

Barbas H, Mesulam MM. Organization of afferent input to subdivisions of area 8 in the rhesus monkey. J Comp Neurol. 1981 Aug 10;200(3):407-31.

Study ID Numbers:	930170, 93-M-0170
Study First Received:	November 3, 1999
Last Updated:	November 13, 2008
ClinicalTrials.gov Identifier:	NCT00001360
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Cognition
Vision
Cortex
Visual Processing
Magnetic Resonance Imaging

Study placed in the following topic categories:

Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Healthy

Dementia
Cognition Disorders
Delirium

ClinicalTrials.gov processed this record on January 15, 2009