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| Sponsored by: |
National Eye Institute (NEI) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00001346 |
Purpose
The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.
| Condition |
|---|
|
Diabetic Retinopathy Macular Degeneration Vision, Subnormal |
| Study Type: | Observational |
| Official Title: | Diabetic Retinopathy and Visual Function Study |
| Estimated Enrollment: | 100 |
| Study Start Date: | November 1992 |
| Estimated Study Completion Date: | October 2000 |
The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Patients with diabetic retinopathy that has not been previously treated are eligible for the study.
Patients who have had laser photocoagulation (either focal or scatter) are not eligible.
Contacts and Locations More Information
| Study ID Numbers: | 930037, 93-EI-0037 |
| Study First Received: | November 3, 1999 |
| Last Updated: | March 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00001346 |
| Health Authority: | United States: Federal Government |
|
Diabetic Macular Edema Diabetic Retinopathy Macular Edema |
Photocoagulation Psychophysical Testing Stiles-Crawford Effect |
|
Sensation Disorders Vision Disorders Eye Diseases Vascular Diseases Diabetes Mellitus Macular Degeneration Edema Endocrine System Diseases Retinal Degeneration Vision, Low |
Diabetic Angiopathies Signs and Symptoms Macular Edema Diabetic Retinopathy Neurologic Manifestations Endocrinopathy Retinal Diseases Diabetes Complications Retinal degeneration |
|
Nervous System Diseases Cardiovascular Diseases |
