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Sponsored by: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001343 |
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical changes normally associated with puberty. In addition, some patients with Turner syndrome have low bone density (osteoporosis) and differences in learning abilities.
This study will research the effects of steroid hormones on patients with Turner syndrome. It will look closely at how taking steroid hormones effects the patient's rate of growth as well as the patient's ability to learn. In addition the study will investigate how different hormones (androgen and estrogen) work when given together as a combination.
All patients asked to participate in this study will receive growth hormone injections. However, half of the patients will receive an additional sex steroid hormone (oxandrolone) in the form of a pill. The other half of the patients will receive a placebo or "sugar pill". This will allow the researchers to determine if the combination of the hormones produces different results than growth hormone alone.
The study will last approximately 2 years. After 2 years of research the patients may qualify for an additional 2 years of treatment. Patients may benefit directly from this research with increased growth and improved ability to learn.
Condition | Intervention | Phase |
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Dwarfism Turner's Syndrome |
Drug: Humatrope Drug: Oxandrolone |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | The Relative Effects of Androgen, Estrogen, and the Combination of Androgen and Estrogen on Growth Rate, GH Binding Protein, IGF-I, and Cognitive Function in Growth Hormone-Treated Girls With Turner Syndrome |
Estimated Enrollment: | 80 |
Study Start Date: | December 1992 |
Estimated Study Completion Date: | October 2007 |
Turner syndrome is associated with short stature, multiple physical stigmata, and absent pubertal development. We propose to: (1) examine the effects of sex steroids (androgen) on multiple variables (growth rate, GH binding protein, IGF-I, and cognitive function), in the setting of supplemental growth hormone administration and (2) to investigate any synergistic or additive effects of the androgen and estrogen combination on the above variables.
Ages Eligible for Study: | 10 Years to 14 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Girls with Turner syndrome will qualify to participate in this study if they meet the following criteria:
Karyotype diagnosis compatible with Turner syndrome.
No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no treatment with either of these agents in the preceding 3 months.
Chronological age of 10.0 to 14.9 years.
Bone age less than or equal to 12 years.
EXCLUSION CRITERIA:
Prior treatment with estrogen, androgen, or growth hormone for more than twelve months.
Y component in peripheral karyotype.
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | |
Bethesda, Maryland, United States, 20892 | |
United States, Pennsylvania | |
Thomas Jefferson University | |
Philadelphia, Pennsylvania, United States, 19107-6541 |
Study ID Numbers: | 930054, 93-CH-0054 |
Study First Received: | November 3, 1999 |
Last Updated: | October 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00001343 |
Health Authority: | United States: Federal Government |
Turner's Syndrome Short Stature Cognitive Function Sex Steroids |
Turner's Syndrome Turner Syndrome TS |
Chromosomal abnormalities Dwarfism Genital dwarfism Gonadal Disorders Chromosome Disorders Endocrine System Diseases Bone Diseases Sex Differentiation Disorders Monosomy X Oxandrolone Turner Syndrome |
Gonadal dysgenesis Urogenital Abnormalities Musculoskeletal Diseases Genetic Diseases, Inborn Turner syndrome Bone Diseases, Developmental Ovarian dwarfism Endocrinopathy Congenital Abnormalities Gonadal Dysgenesis |
Anabolic Agents Pathologic Processes Disease Syndrome Physiological Effects of Drugs |
Hormones, Hormone Substitutes, and Hormone Antagonists Sex Chromosome Disorders Hormones Pharmacologic Actions Androgens |