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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001323 |
The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers.
Participants in this study will undergo cognitive tests of attention, memory, attention. Participants with attention deficit hyperactivity disorder (ADHD), traumatic brain injury (TBI), bipolar disorder, and Alzheimer's disease (AD) will be compared with participants with schizophrenia. A group of healthy adults and children will undergo cognitive tests to further delineate the degree of impairment in schizophrenia and neurological disorder participants.
Condition |
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Brain Injury Dementia Healthy Mental Disorder Schizophrenia |
Study Type: | Observational |
Official Title: | Neuropsychiatric Evaluation of Normal Subjects and Psychiatric and Neurologic Contrast Groups |
Estimated Enrollment: | 810 |
Study Start Date: | August 1992 |
Estimated Study Completion Date: | August 2005 |
In this study, we propose to administer cognitive tests to schizophrenic patients and to neurologic patients who will serve as contrast groups for neuropsychological studies of patients with schizophrenia. These include studies of Alzheimers disease to dissociate size and organization of lexicon and ADHD to understand error patterns on CPT-type tests of attention and vigilance. However, the majority of studies will examine schizophrenia in relation to normal controls.
In addition, we propose to obtain test results from a local sample of normal subjects of varying ages and educational backgrounds to further delineate degree of impairment in these clinical groups. As well as assessing adults we wish to assess normal children. In particular, we wish to identify in children the size of their lexicon and their degree of semantic organization within their lexicon.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA
English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse.
Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections.
Normal controls will be recruited and screened for exclusionary morbidity by interview (e.g., no history of contact with mental health professionals, no history of diagnosable alcohol and/or substance abuse).
Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public.
EXCLUSION CRITERIA
Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID.
Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.
Study ID Numbers: | 920262, 92-M-0262 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001323 |
Health Authority: | United States: Federal Government |
Cognition Neuropsychology Neuropsychological Tests Neurological Exam Psychiatric |
Attention Schizophrenic Schizoaffective Working Memory Memory |
Craniocerebral Trauma Wounds and Injuries Central Nervous System Diseases Disorders of Environmental Origin Healthy Trauma, Nervous System Brain Diseases Cognition Disorders |
Schizophrenia Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Psychotic Disorders Brain Injuries Dementia Schizophrenia and Disorders with Psychotic Features Delirium |
Nervous System Diseases |