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Sponsored by: |
National Eye Institute (NEI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001310 |
The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.
Condition |
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Conjunctival Disease Corneal Disease Eye Disease Uveitis Vitreoretinopathy, Proliferative |
Study Type: | Observational |
Official Title: | Immunopathology and Molecular Pathology of Ocular Diseases in Humans |
Estimated Enrollment: | 4000 |
Study Start Date: | March 1992 |
The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival, corneal, uveal, vitreoretinal and optic nerve disorders, ocular degenerative, metabolic or genetic diseases and tumors. These will be studied using light microscopy, electron microscopy, confocal microscopy, immunohistochemistry, molecular pathological including polymerase chain reaction and in situ hybridization, as well as measuring the functions of cellular organelles, e.g., mitochondrial function. Lymphocytes in the peripheral blood as well as other involved biopsied tissues and ocular tissue will be compared and categorized by disease. Cytokines, chemokines or growth factors in the blood and ocular fluids will be also analyzed. Elucidating the relationship between the infiltrating cells, ocular resident cells, and their products in various diseases will help us to make diagnoses and increase our understanding of human ocular disorders.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
INCLUSION CRITERIA:
EXCLUSION CRITERIA:
1. Participant is unwilling or unable to give informed consent.
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 920113, 92-EI-0113 |
Study First Received: | November 3, 1999 |
Last Updated: | January 3, 2009 |
ClinicalTrials.gov Identifier: | NCT00001310 |
Health Authority: | United States: Federal Government |
Ocular Pathology Ocular Immunology Clinicopathological Correlation Immunohistochemical Methods |
In Situ Hybridization Polymerase Chain Reaction Microdissection Ocular Disease |
Corneal Diseases Uveitis Eye Diseases |
Vitreoretinopathy, Proliferative Retinal Diseases Conjunctival Diseases |
Uveal Diseases |