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Sponsored by: |
National Cancer Institute (NCI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001294 |
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes of HIV infection in male homosexuals is affected by host susceptibility genes, circulating sex hormone levels, or HLA haplotype; and 3) that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis and/or influenced by candidate behavioral loci. The subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation. All subjects will be adults, and will be referred through NIH physicians, private practitioners, and gay and lesbian organizations. Subjects will undergo a sexual orientation and behaviors interview, a psychiatric interview, and phlebotomy for HIV testing, HLA determination, endocrine measurements, and preparation of DNA from cultured lymphocytes. The DNA samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function.
Condition |
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Alcoholism HIV Infection Homosexuality Kaposi's Sarcoma |
Study Type: | Observational |
Official Title: | Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens |
Estimated Enrollment: | 2000 |
Study Start Date: | January 1992 |
Estimated Study Completion Date: | April 2005 |
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes of HIV infection in male homosexuals is affected by host susceptibility genes, circulating sex hormone levels, or HLA haplotype; and 3) that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis and/or influenced by candidate behavioral loci. The subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation. All subjects will be adults, and will be referred through NIH physicians, private practitioners, and gay and lesbian organizations. Subjects will undergo a sexual orientation and behaviors interview, a psychiatric interview, and phlebotomy for HIV testing, HLA determination, endocrine measurements, and preparation of DNA from cultured lymphocytes. The DNA samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
The basic criterion for entering families into the DNA linkage study is the presence of two or more homosexual siblings of the same sex. Additional criteria will be imposed depending on the aims of the particular project.
Study ID Numbers: | 920078, 92-C-0078 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001294 |
Health Authority: | United States: Federal Government |
Genetic Linkage Sex Behavior AIDS |
Alcohol Dependence HLA System Cancer |
Sexually Transmitted Diseases, Viral Disease Susceptibility Malignant mesenchymal tumor Acquired Immunodeficiency Syndrome Sarcoma, Kaposi Disorders of Environmental Origin Soft tissue sarcomas Immunologic Deficiency Syndromes Herpesviridae Infections Virus Diseases Neoplasms, Connective and Soft Tissue Kaposi sarcoma |
Mental Disorders HIV Infections Alcoholism Sexually Transmitted Diseases Substance-Related Disorders Sarcoma DNA Virus Infections Alcohol-Related Disorders Genetic Predisposition to Disease Retroviridae Infections Ethanol |
Neoplasms Disease Attributes RNA Virus Infections Neoplasms by Histologic Type Pathologic Processes |
Slow Virus Diseases Immune System Diseases Neoplasms, Vascular Tissue Lentivirus Infections Infection |