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Sponsored by: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001242 |
Patients with confirmed or suspected conditions with a resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment, and inclusion in other studies pertaining to similar conditions.
This study will provide information about problems relating to calcium in the blood, urine, and bones. Patients in this study will undergo a general evaluation / check-up to give researchers an idea of each person's condition or disease. Patients will receive treatment based on their diagnosis and asked to provide specimen samples for further research studies.
Condition |
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Hypocalcemia Osteomalacia Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Rickets |
Study Type: | Observational |
Official Title: | Studies of States With Resistance to Vitamin D and Parathyroid Hormone |
Study Start Date: | September 1989 |
Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Resistance to a factor is manifested by deficient bioeffect despite high levels of the factor in blood. Patients will be tested with multiple indices of mineral metabolism to establish the diagnosis and examine the spectrum of the underlying disorder. The principal therapies will be combinations of calcium, phosphate, and a vitamin D analog. Selected patients will have localization and surgery to remove a tumor that causes renal wasting of phosphate. Patients will be considered for entry into other research protocols.
Ages Eligible for Study: | 1 Year and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients of any age or sex with vitamin D resistance, rickets, osteomalacia, pseudohypoparathyroidism, pseudo-pseudohypoparathyroidism, or suspicion of these or related disorders based upon the appropriateness of their problem to ongoing investigations.
Current investigations are focused primarily upon subjects with target tissue resistance to 1,25-dihydroxyvitamin D, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism.
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 890173, 89-DK-0173 |
Study First Received: | November 3, 1999 |
Last Updated: | July 19, 2008 |
ClinicalTrials.gov Identifier: | NCT00001242 |
Health Authority: | United States: Federal Government |
Calcium Vitamin D Calcitriol |
Parathyroid Cyclic AMP Rickets |
Vitamin D Deficiency Hypocalcemia Metabolic Diseases Avitaminosis Ergocalciferols Vitamin D resistant rickets Bone Diseases, Metabolic Albright's hereditary osteodystrophy Bone Diseases Calcitriol Calcium, Dietary Metabolism, Inborn Errors |
Pseudohypoparathyroidism Vitamin D Malnutrition Genetic Diseases, Inborn Musculoskeletal Diseases Rickets Pseudopseudohypoparathyroidism Nutrition Disorders Water-Electrolyte Imbalance Osteomalacia Metabolic disorder Deficiency Diseases |
Calcium Metabolism Disorders Growth Substances Vitamins Physiological Effects of Drugs |
Bone Density Conservation Agents Micronutrients Metal Metabolism, Inborn Errors Pharmacologic Actions |