Neuropsychological Evaluation of Psychiatric and Neurological Patients - Full Text View

Sponsored by:	National Institute of Mental Health (NIMH)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001192

Purpose

This study will allow researchers to use various types of tests to evaluate cognitive and sensory functions. These tests, referred to as "batteries" will evaluate attention, executive functions, general intellectual functioning, language, memory, motor functions, orientation, personality, selected sensory and perceptual functions, vigilance (alertness), and visual-spatial functions. Children and adult patient will receive different test batteries.

The goals of this research study are to;

Create descriptions based on the performance of each patient on the test batteries. Then use this information to relate patient behavior to their neurophysiological, neuroradiological, and biochemical descriptions.
Define subgroups of patients based on their neurobehavior in order to decrease the variability of psychiatric diagnoses, treatments, and prognoses.

Condition
Anxiety Disorder Head Injury Mood Disorder Schizophrenia Seizures

Genetics Home Reference related topics: pyridoxine-dependent epilepsy

MedlinePlus related topics: Anxiety Memory Schizophrenia Seizures

U.S. FDA Resources

Study Type:	Observational
Official Title:	Neuropsychological Evaluation of Psychiatric and Neurological Patients

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	4300
Study Start Date:	October 1983
Estimated Study Completion Date:	December 2006

Detailed Description:

Neuropsychological tests are used to provide an assessment of cognitive functions in patients with idiopathic generalized epileptic (IGE) disorders and their first-degree relatives. The battery comprises tests designed to tap attention, memory, selected sensory and perceptual functions, vigilance, and visual-spatial functions. Modified batteries have been developed for the assessment of children ages 5-8, and children ages 8-16. The data provided by these batteries are compared with genetic profiles of the same participants that have been ascertained from blood samples analyzed by colleagues at the Mount Sinai School of Medicine/Columbia University in New York City.

Eligibility

Ages Eligible for Study:	up to 95 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Patients.

Normal volunteers.

EXCLUSION CRITERIA:

Subjects over 95 years of age.

Subjects with a history of alcohol or drug abuse, psychopathology, or central nervous system pathology, other than that which defines group membership, may be excluded.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001192

Locations

United States, District of Columbia
Childrens National Medical Center
Washington, District of Columbia, United States
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
United States, Michigan
Henry Ford Health Systems
Detroit, Michigan, United States, 48202
United States, New York
Mt. Sinai Medical Center
New York, New York, United States, 10029-0574
Columbia University
New York, New York, United States, 10032-3784
France
Genethon
Every Cedex, France
Russian Federation
Mosco Research Institute of Psychiatry
Moscow, Russian Federation

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

More Information

Publications:

Johnstone EC, Owens DG, Bydder GM, Colter N, Crow TJ, Frith CD. The spectrum of structural brain changes in schizophrenia: age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates. Psychol Med. 1989 Feb;19(1):91-103.

Study ID Numbers:	830176, 83-M-0176
Study First Received:	November 3, 1999
Last Updated:	March 5, 2008
ClinicalTrials.gov Identifier:	NCT00001192
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Executive Functions
Language
Attention
Visual-Spatial Ability
Memory
Motor Behavior

Intelligence
Personality
Visual and Auditory Functioning
Hand and Eye Dominance
Normal Volunteer
Neuropsychiatric Disorders

Study placed in the following topic categories:

Schizophrenia
Craniocerebral Trauma
Anxiety Disorders
Mental Disorders
Seizures
Wounds and Injuries

Mood Disorders
Disorders of Environmental Origin
Psychotic Disorders
Trauma, Nervous System
Schizophrenia and Disorders with Psychotic Features

Additional relevant MeSH terms:

Pathologic Processes
Disease
Nervous System Diseases

ClinicalTrials.gov processed this record on January 15, 2009