Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure - Full Text View

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001176

Purpose

Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.

Previous studies conducted on patients with salt sensitive hypertension suggest that their portion of the nervous system responsible for maintaining normal blood pressure (autonomic nervous system) may respond differently to salt than patients with non-salt sensitive (NSS) hypertension.

This study is designed to examine the response of the nervous system to high doses of salt in patients with salt-sensitive hypertension and patients with non-salt sensitive hypertension.

Condition
Hyperaldosteronism Hypertension

MedlinePlus related topics: Dietary Sodium High Blood Pressure

Drug Information available for: Sodium chloride Dopamine Dopamine hydrochloride

U.S. FDA Resources

Study Type:	Observational
Official Title:	The Function of Dopaminergic and Noradrenergic Systems in Salt-Sensitive Hypertension: The Effects of Changes in Sodium Intake

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	110
Study Start Date:	May 1981
Estimated Study Completion Date:	December 2001

Detailed Description:

A subset of patients with idiopathic hypertension shows an increase in blood pressure of 10 percent or more in response to salt-loading and have been termed "salt-sensitive" (SS). Limited studies of adrenergic function in response to salt-loading suggest that the response of SS patients may differ from that of non-salt sensitive (NSS) patients. The present studies were designed to examine the response of the adrenergic and dopaminergic systems to salt-loading in SS and NSS patients with idiopathic hypertension.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Eligibility criteria not identified in protocol.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001176

Locations

United States, Maryland
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

More Information

Publications:

Kawasaki T, Delea CS, Bartter FC, Smith H. The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med. 1978 Feb;64(2):193-8.

Fujita T, Henry WL, Bartter FC, Lake CR, Delea CS. Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med. 1980 Sep;69(3):334-44. No abstract available.

Alexander RW, Gill JR Jr, Yamabe H, Lovenberg W, Keiser HR. Effects of dietary sodium and of acute saline infusion on the interrelationship between dopamine excretion and adrenergic activity in man. J Clin Invest. 1974 Jul;54(1):194-200. No abstract available.

Study ID Numbers:	810081, 81-H-0081
Study First Received:	November 3, 1999
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00001176
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Adrenergic Nervous System
Dopaminergic Nervous System
Salt-Sensitive Hypertension
Hypertension
Primary Aldosteronism

Study placed in the following topic categories:

Dopamine
Vascular Diseases
Endocrine System Diseases
Adrenal Gland Diseases
Endocrinopathy

Conn's syndrome
Adrenocortical Hyperfunction
Hyperaldosteronism
Primary aldosteronism
Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 15, 2009