Magnesium in Coronaries (MAGIC)

This study has been completed.

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:	NCT00000610

Purpose

To determine whether early intravenous magnesium treatment of patients with suspected acute myocardial infarction reduces mortality.

Condition	Intervention	Phase
Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Infarction Myocardial Ischemia	Drug: magnesium	Phase III

MedlinePlus related topics: Coronary Artery Disease Heart Attack Heart Diseases

Drug Information available for: Magnesium

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Placebo Control

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	April 1998
Estimated Study Completion Date:	November 2003

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Patients with suspected acute myocardial infarction (presenting with ST elevation on the electrocardiogram) and who were at (relatively) high risk for mortality.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000610

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Investigator:

Sonja McKinlay

New England Research Institutes, Inc.

More Information

Publications:

[No authors listed] Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction. The MAGIC Steering Committee. Am Heart J. 2000 Jan;139(1 Pt 1):10-4.

[No authors listed] Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002 Oct 19;360(9341):1189-96.

Domanski M, Antman EM, McKinlay S, Varshavsky S, Platonov P, Assmann SF, Norman J. Geographic variability in patient characteristics, treatment and outcome in an International Trial of Magnesium in acute myocardial infarction. Control Clin Trials. 2004 Dec;25(6):553-62.

Cooper HA, Domanski MJ, Rosenberg Y, Norman J, Scott JH, Assmann SF, McKinlay SM, Hochman JS, Antman EM; Magnesium in Coronaries trial investigators. Acute ST-segment elevation myocardial infarction and prior stroke: an analysis from the Magnesium in Coronaries (MAGIC) trial. Am Heart J. 2004 Dec;148(6):1012-9.

Study ID Numbers:	113
Study First Received:	October 27, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00000610
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Arterial Occlusive Diseases
Coronary Disease
Necrosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Arteriosclerosis
Ischemia
Infarction
Myocardial Infarction
Coronary Artery Disease

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 15, 2009