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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00000579 |
The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical Care Treatment Groups (CCTGs) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs, approved agents not currently used for treatment of ARDS, or treatments currently used but whose efficacy has not been well documented.
Condition | Intervention | Phase |
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Respiratory Distress Syndrome, Adult Lung Diseases |
Procedure: Low Tidal Volume Ventilation Procedure: Positive End-Expiratory Pressure Drug: Lysofylline Drug: Methylprednisolone Drug: Ketoconazole Procedure: Fluid Management Procedure: Pulmonary Artery Catheter |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Placebo Control, Factorial Assignment |
Official Title: | Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) |
Study Start Date: | September 1994 |
Ages Eligible for Study: | 13 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Principal Investigator: | Edward Abraham, MD | University of Colorado at Denver and Health Sciences Center |
Principal Investigator: | Antonio Anzueto, MD | University of Texas |
Principal Investigator: | Roy Brower, MD | Johns Hopkins University |
Principal Investigator: | Alfred F. Connors, MD | University of Virginia |
Principal Investigator: | Bennett P. deBoisblanc, MD | Louisiana State University |
Principal Investigator: | Bennett P. deBoisblanc, MD | Louisiana State University Health Science Center |
Principal Investigator: | Michael Donahoe, MD | University of Pittsburgh |
Principal Investigator: | Kalpalatha K. Guntupalli, MD | Baylor College of Medicine |
Principal Investigator: | Robert D. Hite, MD | Wake Forest University |
Principal Investigator: | Robert D. Hite, MD | Wake Forest University |
Principal Investigator: | Rolf Hubmayr, MD | Mayo Clinic |
Principal Investigator: | Neil MacIntyre, MD | Duke University |
Principal Investigator: | Michael A. Matthay, MD | University of California, San Francisco |
Principal Investigator: | Alan Morris, MD | Latter Day Saints Hospital |
Principal Investigator: | Michael J. Murray | Mayo Foundation |
Principal Investigator: | James A. Russell, MD | University of British Columbia |
Principal Investigator: | Gregory A. Schmidt, MD, FCCP | University of Chicago |
Principal Investigator: | David A. Schoenfeld, PhD | Massachusetts General Hospital |
Principal Investigator: | Jay S. Steingrub, MD, FCCP | Baystate Medical Center |
Principal Investigator: | Arthur Wheeler, MD | Vanderbilt University |
Principal Investigator: | Herbert Wiedemann, MD | Cleveland Clinic Lerner College of Medicine |
Study ID Numbers: | 217, N01 HR16146, N01 HR16147, N01 HR16148, N01 HR16149, N01 HR16150, N01 HR16151, N01 HR16152, N01 HR16153, N01 HR16154, N01 HR16155, N01 HR46054, N01 HR46055, N01 HR46056, N01 HR46057, N01 HR46058, N01 HR46059, N01 HR46060, N01 HR46061, N01 HR46062, N01 HR46063, N01 HR46064, N01 HR56165, N01 HR56166, N01 HR56167, N01 HR56168, N01 HR56169, N01 HR56170, N01 HR56171, N01 HR56172, N01 HR56173, N01 HR56174, N01 HR56175, N01 HR56176, N01 HR56179 |
Study First Received: | October 27, 1999 |
Last Updated: | August 24, 2006 |
ClinicalTrials.gov Identifier: | NCT00000579 |
Health Authority: | United States: Federal Government |
Methylprednisolone Clotrimazole Miconazole Respiratory Distress Syndrome, Adult Respiration Disorders Tioconazole Methylprednisolone acetate |
Prednisolone acetate Ketoconazole Respiratory Tract Diseases Lung Diseases Prednisolone Acute respiratory distress syndrome Methylprednisolone Hemisuccinate |
Anti-Inflammatory Agents Anti-Infective Agents Disease Antineoplastic Agents, Hormonal Antineoplastic Agents Physiological Effects of Drugs Hormones, Hormone Substitutes, and Hormone Antagonists Gastrointestinal Agents Antiemetics Hormones Glucocorticoids |
Protective Agents Neuroprotective Agents Pharmacologic Actions Pathologic Processes Autonomic Agents Syndrome Antifungal Agents Therapeutic Uses Peripheral Nervous System Agents Central Nervous System Agents |