Sevoflurane Vs Isoflurane Inhalation at Subanesthetic Concentrations - 11

This study has been completed.

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) University of Chicago
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000259

Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Condition	Intervention	Phase
Opioid-Related Disorders Substance-Related Disorders	Drug: Nitrous oxide	Phase II

Drug Information available for: Sevoflurane Isoflurane Nitrous oxide

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment
Official Title:	Sevoflurane Vs Isoflurane Inhalation at Subanesthetic Concentrations

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:

Pain intensity, pain bothersomeness
Mood
Psychomotor performance
Cognitive performance
Pain quality
Peripheral drug effect

Estimated Enrollment:	0
Study Start Date:	August 1996

Eligibility

Ages Eligible for Study:	21 Years to 39 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000259

Locations

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

University of Chicago

Investigators

Principal Investigator:

James Zacny, Ph.D.

University of Chicago

More Information

Study ID Numbers:	NIDA-08391-11, R01-08391-11
Study First Received:	September 20, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00000259
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Mental Disorders
Nitrous Oxide
Isoflurane
Substance-Related Disorders

Disorders of Environmental Origin
Opioid-Related Disorders
Sevoflurane

Additional relevant MeSH terms:

Disease
Hematologic Agents
Physiological Effects of Drugs
Anesthetics
Central Nervous System Depressants
Pharmacologic Actions
Anesthetics, Inhalation
Pathologic Processes

Anesthetics, General
Analgesics, Non-Narcotic
Sensory System Agents
Therapeutic Uses
Platelet Aggregation Inhibitors
Peripheral Nervous System Agents
Analgesics
Central Nervous System Agents

ClinicalTrials.gov processed this record on January 15, 2009