Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

This study has been completed.

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) University of Chicago
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000250

Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Condition	Intervention	Phase
Opioid-Related Disorders Substance-Related Disorders	Drug: Nitrous oxide	Phase II

MedlinePlus related topics: Drinking Water

Drug Information available for: Nitrous oxide

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment
Official Title:	Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:

Pain intensity, pain bothersomeness
Mood
Psychomotor performance
Choice of nitrous oxide vs. placebo

Estimated Enrollment:	0
Study Start Date:	December 1993

Eligibility

Ages Eligible for Study:	21 Years to 32 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000250

Locations

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

University of Chicago

Investigators

Principal Investigator:

James Zacny, Ph.D.

University of Chicago

More Information

Study ID Numbers:	NIDA-08391-2, R01-08391-2
Study First Received:	September 20, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00000250
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Mental Disorders
Nitrous Oxide
Substance-Related Disorders
Disorders of Environmental Origin
Opioid-Related Disorders

Additional relevant MeSH terms:

Disease
Physiological Effects of Drugs
Central Nervous System Depressants
Anesthetics
Pharmacologic Actions
Anesthetics, Inhalation
Pathologic Processes

Analgesics, Non-Narcotic
Sensory System Agents
Anesthetics, General
Therapeutic Uses
Analgesics
Peripheral Nervous System Agents
Central Nervous System Agents

ClinicalTrials.gov processed this record on January 15, 2009