Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1

This study has been completed.

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) Friends Research Institute, Inc.
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000245

Purpose

The purpose of this study is to confirm whether a blood level ""ceiling"" exists on desipramine effect in cocaine abuse.

Condition	Intervention	Phase
Cocaine-Related Disorders Substance-Related Disorders	Drug: Desipramine	Phase II

Drug Information available for: Desipramine Desipramine hydrochloride 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))- Cocaine hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment
Official Title:	Evaluation of a Desipramine Ceiling in Cocaine Abuse

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:

Craving
Retention
Cocaine use
Depression
Anxiety
Mood indicators

Estimated Enrollment:	0
Study Start Date:	May 1994
Estimated Study Completion Date:	December 2001

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000245

Locations

United States, California
Friends Research Institute
Los Angeles, California, United States, 90025

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

Friends Research Institute, Inc.

Investigators

Principal Investigator:

Frank Gawin, M.D.

Friends Research Institute, Inc.

More Information

Study ID Numbers:	NIDA-08082-1, R01-08082-1
Study First Received:	September 20, 1999
Last Updated:	August 16, 2005
ClinicalTrials.gov Identifier:	NCT00000245
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Cocaine-Related Disorders
Mental Disorders
Substance-Related Disorders

Disorders of Environmental Origin
Desipramine
Cocaine

Additional relevant MeSH terms:

Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Disease
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Adrenergic Uptake Inhibitors
Physiological Effects of Drugs
Psychotropic Drugs

Enzyme Inhibitors
Pharmacologic Actions
Antidepressive Agents, Tricyclic
Pathologic Processes
Therapeutic Uses
Central Nervous System Agents
Antidepressive Agents

ClinicalTrials.gov processed this record on January 15, 2009