Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
National Institute on Aging (NIA) |
---|---|
Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00000180 |
AIT-082 is a novel small molecule that crosses the blood-brain barrier to enhance nerve function by increasing levels of neurotrophic growth factors and encouraging nerve sprouting in the brain. Preclinical studies in animals have shown that AIT-082 improves memory in aged animals and in animals with neurological deficits.
This study was a double-blind placebo-controlled safety study that was designed to study whether AIT-082 may delay age-related mental decline. Eight healthy older volunteers at two clinical sites were given single, weekly, rising doses of AIT-082 or placebo for 5 weeks; were tested for side effects and absorption; and underwent a battery of neuropsychological memory tests, including word and number recall tests.
Condition | Intervention | Phase |
---|---|---|
Memory Disorders |
Drug: AIT-082 |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
United States, California | |
University of California, San Diego | |
San Diego, California, United States, 92093-0949 | |
United States, Indiana | |
Indiana University Alzheimer's Center | |
Indianapolis, Indiana, United States, 46202 | |
United States, Michigan | |
University of Michigan | |
Ann Arbor, Michigan, United States, 48109-0322 | |
United States, Missouri | |
Washington University | |
St. Louis, Missouri, United States, 63110 |
Principal Investigator: | Michael Grundman, M.D., M.P.H. | University of California, San Diego |
Study ID Numbers: | IA0008, 3U01AG10483-08S2 |
Study First Received: | October 29, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00000180 |
Health Authority: | United States: Federal Government |
Memory Mild cognitive impairment Nerve growth factors |
Signs and Symptoms Neurologic Manifestations Neurobehavioral Manifestations Memory Disorders |
Nervous System Diseases |