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Abstract

Title: Common variants of FUT2 are associated with plasma vitamin B12 levels.
Author: Hazra A,Kraft P,Selhub J,Giovannucci EL,Thomas G,Hoover RN,Chanock SJ,Hunter DJ
Journal: Nat Genet 40(10):1160-2
Year: 2008
Month: October

Abstract: We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.