Magnetic Resonance Imaging Follow-up on Temporomandibular Arthritis in Children With Juvenile Idiopathic Arthritis - Full Text View

Sponsored by:	University Hospital Tuebingen
Information provided by:	University Hospital Tuebingen
ClinicalTrials.gov Identifier:	NCT00801593

Purpose

Children with juvenile idiopathic arthritis (JIA) suffer in up to 87% of the cases of arthritis of the temporomandibular joints (TMJs). Magnetic resonance imaging (MRI) is the only modality for the early diagnosis of TMJ involvement.

Aim of the study is to compare symptoms and clinical findings with MRI and ultrasonography results and to describe the action of the current medication on the arthritis of the TMJs.

Condition	Intervention
Juvenile Idiopathic Arthritis	Procedure: Steroid injection into the TMJs.

MedlinePlus related topics: Juvenile Rheumatoid Arthritis MRI Scans Ultrasound

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Arthritis of the Temporomandibular Joints in Children With Juvenile Idiopathic Arthritis- Pilot Study on Diagnostic Value of Ultrasonography and Magnetic Resonance Imaging and Influence of Drug Treatment

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:

TMJ arthritis on MRI [ Time Frame: every three to six months from recruitment to end of study ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

TMJ arthritis on ultrasound [ Time Frame: every three to six months from recruitment to end of study ] [ Designated as safety issue: No ]
Action of current medication on TMJ arthritis. [ Time Frame: every three to six months from recruitment to end of study ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	50
Study Start Date:	May 2008
Estimated Study Completion Date:	June 2010
Estimated Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
Children with JIA	Procedure: Steroid injection into the TMJs. In case of otherwise noncontrollable TMJ involvement steroids are injected into arthritic TMJs under MRI guidance.

Eligibility

Ages Eligible for Study:	7 Years to 17 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Children with JIA.

Criteria

Inclusion Criteria:

Children with defined JIA.

Exclusion Criteria:

Children without defined diagnosis of JIA.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00801593

Contacts

Contact: Nikolay Tzaribachev, MD

+49707129 ext 84711

nikolay.tzaribachev@med.uni-tuebingen.de

Locations

Germany, Baden-Wuerttemberg
University Children's Hospital	Recruiting
Tuebingen, Baden-Wuerttemberg, Germany, 72076
Contact: Nikolay Tzaribachev, MD +49707129 ext 84711 nikolay.tzaribachev@med.uni-tuebingen.de
Principal Investigator: Nikolay Tzaribachev, MD

Sponsors and Collaborators

University Hospital Tuebingen

Investigators

Principal Investigator:

Nikolay Tzaribachev, MD

University Hospital Tuebingen

More Information

Responsible Party:	University Children's Hospital, Tuebingen ( Nikolay Tzaribachev, Dr. )
Study ID Numbers:	TMJ PROSPECT2008
Study First Received:	December 2, 2008
Last Updated:	December 2, 2008
ClinicalTrials.gov Identifier:	NCT00801593
Health Authority:	Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by University Hospital Tuebingen:

JIA

Study placed in the following topic categories:

Autoimmune Diseases
Arthritis, Juvenile Rheumatoid
Musculoskeletal Diseases
Joint Diseases

Arthritis
Connective Tissue Diseases
Arthritis, Rheumatoid
Rheumatic Diseases

Additional relevant MeSH terms:

Immune System Diseases

ClinicalTrials.gov processed this record on January 16, 2009