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Sponsored by: |
Duke-NUS Graduate Medical School |
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Information provided by: | Duke-NUS Graduate Medical School |
ClinicalTrials.gov Identifier: | NCT00800553 |
The purpose of this study is to characterize how the anti-cholinesterase inhibitor (AChE-I) donepezil modulates brain regions involved in delayed recognition memory, working memory, and inhibitory efficiency following 24 hours of total sleep deprivation.
Condition | Intervention | Phase |
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Sleep Deprivation |
Drug: donepezil |
Phase IV |
Study Type: | Interventional |
Study Design: | Basic Science, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | The Neural and Behavioral Correlates of How Donepezil Modulates Memory and Inhibitory Efficiency in the Context of 24 Hours of Sleep Deprivation |
Enrollment: | 43 |
Study Start Date: | November 2006 |
Study Completion Date: | May 2007 |
Primary Completion Date: | May 2007 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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donepezil: Experimental
5 mg donepezil, p.o. for approx 2 weeks
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Drug: donepezil
5mg o.m. p.o. for approx. 2 weeks
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placebo: No Intervention |
Ages Eligible for Study: | 21 Years to 35 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Singapore | |
Cognitive Neuroscience Laboratory, Singapore General Hospital Pte Ltd | |
Singapore, Singapore, 169611 |
Principal Investigator: | Michael WL Chee, MD | Duke-NUS Graduate Medical School |
Responsible Party: | Duke-NUS Graduate Medical School ( Michael Chee / Professor ) |
Study ID Numbers: | CRT108999 |
Study First Received: | December 1, 2008 |
Last Updated: | December 1, 2008 |
ClinicalTrials.gov Identifier: | NCT00800553 |
Health Authority: | Singapore: Domain Specific Review Boards |
sleep deprivation fMRI double blind crossover study |
Signs and Symptoms Mental Disorders Donepezil Neurologic Manifestations |
Sleep Disorders Dyssomnias Sleep Deprivation |
Nootropic Agents Cholinesterase Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Therapeutic Uses Physiological Effects of Drugs |
Nervous System Diseases Enzyme Inhibitors Cholinergic Agents Central Nervous System Agents Pharmacologic Actions |