Reproducibility of Magnetic Resonance Myocardial Salvage Index - Full Text View

Sponsored by:	University of Leipzig
Information provided by:	University of Leipzig
ClinicalTrials.gov Identifier:	NCT00794300

Purpose

The myocardial salvage assessed by using multimodal cardiac magnetic resonance imaging is a rather new technique which can be used as a surrogate endpoint to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction. As reproducibility of myocardial salvage has not been evaluated appropriately, we aim to scan 20 patients on 2 subsequent days to evaluate reproducibility of myocardial salvage index.

Condition	Intervention
Myocardial Infarction	Device: second magnetic resonance imaging scan

MedlinePlus related topics: Heart Attack MRI Scans Nuclear Scans

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Reproducibility of Myocardial Salvage Index in Acute Myocardial Infarction by Cardiac Magnetic Resonance Imaging

Further study details as provided by University of Leipzig:

Primary Outcome Measures:

Myocardial salvage index reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

infarct size reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]
area at risk reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]
microvascular obstruction reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Groups/Cohorts	Assigned Interventions
Acute myocardial infarction patients	Device: second magnetic resonance imaging scan

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

ST-elevation myocardial infarction

Criteria

Inclusion Criteria:

ST-elevation myocardial infarction
Primary percutaneous coronary intervention

Exclusion Criteria:

Contraindications for magnetic resonance imaging

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00794300

Locations

Germany
University of Leipzig - Heart Center
Leipzig, Germany, 04289

Sponsors and Collaborators

University of Leipzig

Investigators

Principal Investigator:

Holger Thiele, MD

University of Leipzig

More Information

Study ID Numbers:	Repro100
Study First Received:	November 19, 2008
Last Updated:	November 19, 2008
ClinicalTrials.gov Identifier:	NCT00794300
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Leipzig:

reproducibility
contrast agent
magnetic resonance imaging

infarct size
myocardial salvage index
myocardial salvage assessment

Study placed in the following topic categories:

Necrosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Ischemia
Infarction
Myocardial Infarction

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 13, 2009