National Institute on Drug Abuse
Director's Report to the National Advisory Council on Drug Abuse
September, 1997
Program Activities
Program Announcements/RFAs
Discovery of Novel Pharmacotherapies for Cocaine Dependence RFA
NIDA's Medications Development Division issued an RFA (DA 97-003) entitled "Discovery of Novel Pharmacotherapies for Cocaine Dependence". Twenty-seven (27) applications were reviewed, and it is anticipated that eight (8) will be funded. Three approved applicants are new to the field (no prior NIDA grants) and one applicant is just finishing an R29 (FIRST) award.
Sex and Gender-Related Differences in Pain and Analgesic Response RFA
NIDA will participate in an RFA entitled, "Sex and Gender-Related Differences in Pain and Analgesic Response," RFA No. DE-97-003, P.T. 34, issued in the NIH Guide, volume 26, number 23 on July 18, 1997. Other participants are the National Institute of Dental Research (NIDR), the National Institute of Nursing Research (NINR), and the National Institutes of Health's (NIH) Office of Research on Women's Health (ORWH). This RFA encourages research in sex- or gender- related differences in pain and analgesic response and mechanisms underlying these differences to facilitate targeted, effective, safe treatments for men and women.
B/START-NIDA: Behavioral Science Track Awards for Rapid Transition
(NIH GUIDE March 21, 1997; #PAR-97-046) This announcement has been re-issued as a Program announcement. Newly independent investigators are invited to submit applications for small-scale, exploratory (i.e., pilot) research projects related to NIDA's behavioral sciences mission. B/START-NIDA provides rapid review and funding decisions of applications. Research applications are encouraged across a wide variety of behavioral factors in drug abuse, including neurocognitive, cognitive and perceptual processes, psychosocial, and more broadly motivational, social and community factors in drug abuse. HIV/AIDS applications are especially encouraged. In FY 98 and beyond, there will be two receipt dates per fiscal year: October 1 and February 1.
Other Program Activities
Dissemination of Prevention Research
The NIDA 1998 SBIR Contract Concepts for the first time include a call for proposals to examine mechanisms used to transfer research-based drug abuse prevention information to practitioners, policy makers, and the public. It is anticipated that two contracts will be awarded to examine stages of diffusion. The purpose of this work is to increase the capacity of the research field to disseminate findings in an effective and efficient manner.
Buprenorphine and Buprenorphine/Naloxone Efficacy Trial
The Data Safety Monitoring Board for the Department of Veterans Affairs Cooperative Studies Program reviewed the NIDA Medications Development Division sponsored study (CSP #1008, "A Multicenter Efficacy/Safety Trial of Buprenorphine/Naloxone for the Treatment of Opiate Dependence"). The Board met on June 24, 1997 to review trial data and again on July 17, 1997 to review updated data. On both occasions the Board agreed that the efficacy portion of the study had proven that both buprenorphine alone and the buprenorphine/naloxone combination arms of the trial had conclusively demonstrated that these products were superior to placebo. The differences between these treatment groups on both primary outcomes measures were highly significant (p<0.001) and the likelihood of determining no difference if allowed to go to completion was remote (p<0.005). Therefore, the Board recommended that the efficacy portion of the trial be terminated and that the transfer of current patients to the safety trial be conducted as quickly, efficiently and orderly as possible. This transfer has been completed. Recruitment of patients to the safety trial is continuing, but is expected to be completed by the end of September 1997. The safety portion of the trial will continue for one year.
NIDA/ALGOS Pharmaceutical Company CRADA
A Cooperative Research and Development Agreement (CRADA) between NIDA and ALGOS Pharmaceutical Company was approved on June 17, 1997. This CRADA will investigate the safety and efficacy of the addition of the low affinity NMDA receptor antagonist, dextromethorphan (DM), to methadone in the treatment of withdrawal and relapse associated with opiate addiction. Initial studies have begun at the Philadelphia VA MDRU.
NIDA'S New/Competing Awards Since May 1997
Aldrich, Jane V. --- University of Maryland-Dept. of Pharmaceutical Sciences
Dynorphin Analogs as Kappa Opioid Receptor Antagonists
Allen, Richard G. --- Oregon Health Sciences University
Regulation of Prepro-orphanin Fq (Ofq)-derived Peptides
Ataabadi, Ali N. --- Affiliated Systems Corporation
Cocaine Use, Psychosocial Factors, & AIDS Risk Behaviors
Barnea, Ayalla --- University of Texas Southwestern Medical Center
HIV and Cocaine Interactions in the Developing Brain
Barr, Gordon A. --- Research Foundation for Mental Hygiene Inc.
Development and Plasticity of Opiate Withdrawal
Bentler, Peter M. --- University of California-Dept. of Psychology
Collaborative Research on Drug Abuse
Bornheim, Lester M.--- University of California-Dept. of Pharmacology
Cannabidiol: Effect on Cytochrome P 450 Isozymes
Botvin, Gilbert J. --- Cornell University Medical College-Dept. of Public Health
Multi-ethnic Drug Abuse Prevention among New York Youth
Butler, Stephen F. --- Innovative Training Systems
Computer-based Vocational Intervention for CD Clients
Carey, Kate B. --- Syracuse University
Enhancing Readiness to Change in Schizophrenics
Chang, Jing-Yu --- Bowman Gray School of Medicine
Electrophysiology of Cannabinoid Action on Rat Behaviors
Chavez, Ernest L. --- Colorado State University
Mexican-American Dropouts & Drug Use
Chou, Chih-Ping --- University of Southern California-Dept. of Preventive Medicine
The Random-Effect Models for Substance Abuse Research
Crowley, Thomas J. --- University of Colorado Health Sciences Center
Antisocial Drug Dependence: Genetics and Treatment
Crystal, Stephen --- Rutgers University-Institute for Health
Health Care Use Patterns among Drug Users with HIV/AIDS
Cunningham, Kathryn A. --- University of Texas Medical Branch
FASEB Summer Research Conference: Drug Abuse
D'Aunno, Thomas A. --- University of Chicago-School of Social Services Admin.
The Role of Managed Care Organizations in Drug Treatment
Davis, Thomas P. --- University of Arizona-Dept. of Pharmacology
Blood to CNS Uptake of Opioid Peptide Drugs
Dawes, Michael A. --- University of Pittsburgh Medical Center-Dept. Of Psychiatry
Drug Use Liability During Pubertal Development
Deleo, Joyce A. --- Dartmouth-Hitchcock Medical Center
Alternatives to Opioids for Chronic Pain: Part II
Dey, Sudhansu K. --- University of Kansas Medical Center-Dept.of Physiology
Effects of Marijuana on Early Pregnancy
Drucker, Ernest --- Montefiore Medical Center
Office-Based Methadone Prescribing
Dunlap, Eloise --- National Development & Research Institute
Co-occurring Drugs & Violence in Distressed Households
Eissenberg, Thomas E. --- Virginia Commonwealth Univ.-Center for Drug & Alcohol Studies
Drug Craving: Pharmacologic and Associative Influences
El-bassel, Nabila --- Columbia University-School of Social Work
Partner Abuse: Minority Women on Methadone
Eldefrawi, Mohyee E. --- University of Maryland-School of Medicine-Pharm and Exp. Ther.
Biosensors of Cocaine and Heroin Abuse
Eldridge, Gloria D. --- Jackson State University
HIV Risk Reduction for Women in Drug Treatment
Ellis, Alicja I. --- Essex Consulting, Inc.
Information System for Substance Abuse Practitioners
Fenaughty, Andrea M. --- University of Alaska
Women, Drugs and Condoms: Ecologies of Risk
Fendrich, Michael --- University of Illinois-Dept of Psychiatry
Secondary Analysis of Substance Use Reporting
Ferguson, David M. --- University of Minnesota-Dept. of Medicinal Chemistry
Modeling Opioid Receptor Structure and Function
Freedman, Jonathan E. --- Northeastern University-Dept. of Pharmaceutical Sciences
Opioid Modulated Ion Channels in Limbic Forebrain
George, Frank R. --- Amethyst Technologies, Inc.
Science Education: Neurobiology for Practitioners
Gibb, James W. --- University of Utah-Dept. of Pharmacology/Toxicology
Neurochemical Alterations by Designer Drugs
Glowa, John R. --- Louisiana State Medical Center
Mechanisms of Inhalant Abuse
Goodman, Allen C. --- Wayne State University
Comorbidities, Time to Treatment, and Episode Costs
Gorman, E. Michael --- University of Washington
HIV, Drugs, Sexual Risk in DUMSM: A Community Study
Greenwald, Mark K. --- Wayne State Univ.-Dept. of Psychology & Behavioral Neuroscience
Behavioral Studies with Methadone Clients
Griffiths, Roland R. --- Johns Hopkins University-Bayview Medical Center
Experimental Analysis of Sedative/Stimulant Abuse
Guttmacher, Sally J. --- New York University-Dept. of Health Studies
Capturing High-Risk Students in Classroom-Based Surveys
Gu, Howard H. --- Yale University School of Medicine-Dept. of Pharmacology
Functions of Biogenic Amine Transporters
Hanson, Glen R. --- University of Utah-Dept. of Pharmacology & Toxicology
Drug Abuse and Regulatory Enzymes of Biogenic Amines
Harper, Gary W. --- Depaul University-Dept. of Psychology
HIV Sexual Risk and Substance Use among Homeless Youth
Hienz, Robert D. --- Johns Hopkins University-Bayview Medical Center
Cocaine: Perceptual and Motor Effects
Higgins, Stephen T. --- University of Vermont-Dept. of Psychiatry
Factors Influencing Cocaine Use in Humans
Hoffmann, John P. --- National Opinion Research Center
Community and Family Context of Adolescent Drug Use
Hollander, Eric --- Mount Sinai School of Medicine
Serotonin/Norepinephrine Function: Pathological Gambling
Hoover, Donald R, III --- Johns Hopkins University-Dept. of Epidemiology
Analytical Methods for Observational Drug User Cohorts
Houlihan, William J. --- Drew University
Mazindol Analogs as Cocaine Receptor Antagonists
Howells, Richard D. --- University of Medicine and Dentistry-New Jersey Medical School
Structure/Function Analysis of Opioid Receptor Subtypes
Howell, Leonard L. --- Emory University
PET Imaging and Cocaine Neuropharmacology in Monkeys
Howlett, Allyn C. --- Saint Louis University
Cannabinoid Receptor Pharmacology & Biochemistry
Ho, Begonia Y. --- University of North Dakota-Dept. of Pharmacology and Toxicology
Cellular Signaling of the Cannabinoid Receptor
Ho, Ing Kang --- University of Mississippi Medical Center
Mechanism of Action of Butorphanol
Hruby, Victor J. --- University of Arizona
New Modalities for Treatment of Pain & Drug Abuse
Iguchi, Martin Y. --- Allegheny University of Health Sciences
Methadone Treatment: Behavioral/Phamacological Variables
Inturrisi, Charles E. --- Cornell University Medical College-Dept. of Pharmacology
Pharmacology and Neuroscience of Drug Abuse
Jainchill, Nancy --- National Development & Research Institute, Inc.
Hispanic American/Venezuelan Youth-Drug Use Risk Factors
Janda, Kim D. --- Scripps Research Institute
Immunopharmacotherapy as a Treatment for Cocaine Abuse
Johanson, Chris-Ellyn --- Wayne State Univ.-Dept.of Psych. and Behavioral Neuroscience
Individual Differences in Bio-behavioral Drug Response
Johnson, Karen C. --- University of Tennessee
Treating Nicotine Addiction in Pregnancy
Jones, Reese T. --- University of California-Langley Porter Psychiatric Institute
Neuropsychopharmacology of Altered Consciousness
Justice, Joseph B. --- Emory University-Dept. of Chemistry
Ligand Binding Sites on the Dopamine Transporter
Kaplan, Howard B. --- Texas A&M University
Drug Abuse & Other Deviant Adaptations: Two Generations
Kauer, Julie A. --- Duke University-Dept. of Neurobiology
Glutamate Synapses in Sensitization to Drugs of Abuse
Kessel, Raymond --- University of Wisconsin-Dept. of Health and Human Issues
Teacher/Scientist Partnerships: Impacting Drug Abuse
Kiyatkin, Eugene A. --- Indiana University- Dept. of Psychology
Dopamine Neurons and Heroin Reinforcement
Kleinfeld, David --- University of California San Diego
Work Group on Neuronal Dynamics
Koob, George F. --- Scripps Research Institute
Dopamine Partial Agonists and Cocaine Dependence
Kuhar, Michael J. --- Emory University-Yerkes Primate Research Center
Cocaine Sensitive Dopamine Transporter Synthesis
Laruelle, Marc --- Research Fountation for Mental Hygiene-NewYork State Psych. Inst.
Neurobiology of Cocaine-Induced Sensitization
Latimer, William W. --- Univ. of Minnesota-Division of General Peds. & Adol. Health
A Cognitive-Behavioral Therapy for Drug Abusing Youth
Lester, Henry A. --- California Institute of Technology
Biogenic Amine Transporters: Structure and Function
Leukefeld, Carl G. --- Center for Drug & Alcohol Research
Health Services Use by Chronic Rural Drug Abusers
Levin, Jonathan M. --- McLean Hospital-Brain Imaging Center
Functional Neuroimaging of Drug Abuse
Lipton, Douglas S. --- National Development & Research Institute
Correctional Drug Abuse Treatment Effectiveness
Lipton, Stuart A. --- Childrens Hospital
Cellular/Molecular Pathophysiology of Mental Retardation
Little, Karley Y. --- Veterans Administration Medical Center
Brain DAT/5-htt Dysregulation in Human Cocaine Users
Luborsky, Lester B. --- University of Pennsylvania-Dept. of Psychiatry
Effective Ingredients of Behavioral Therapies for Drug Abuse
Lukas, Scott E. --- McLean Hospital
Pharmacological and Behavioral Indices of Drug Abuse
Lyons, David --- Bowman Gray School of Medicine
Primate Cocaine Abuse and Cytochrome Oxidase Histochemistry
Madras, Bertha K. --- Harvard Medical School
Cocaine: Molecular Targets, Brain Imaging and Medication
Magura, Stephen --- National Development Research Institute
Effectiveness of Self-help for the Dually Diagnosed
Malison, Robert T. --- Yale University School of Medicine
SPECT Imaging of DA Function in Cocaine Dependence
Marley, R. J. --- University of Albany-Dept. of Psychology
Pharmacogenetic Approaches to Cocaine Neuropharmacology
Martin, Billy R. --- Medical College of Virginia
An Investigation of THC Receptors
Martin, Billy R. --- Virginia Commonwealth University
Inhalation of Drugs of Abuse
Matt, George E. --- San Diego State University-Dept. of Psychology
Improving Self-reports of Drug Use: A Cognitive Set Model
Mayes, Linda C. --- Yale Child Study Center
Regulation of Arousal and Attention in Cocaine-exposed Children
McMillan, Donald E. --- University of Arkansas for Medical Sciences
Drugs of Abuse: Chronic Interactions and Behavior
Moises, Hylan C. --- University of Michigan-Dept. of Physiology
Opioid & G-protein Regulation of Calcium Currents
Molitor, Thomas W. --- University of Minnesota-Dept. of Clinical and Population Sciences
Opiate Modulation of Pulmonary Infection
Monti, Peter M. --- Brown University-Center for Alcohol and Addiction Studies
Motivational Interviewing for Teen Smokers
Moody, David E. --- University of Utah-Dept. of Pharmacology & Toxicology
Human Metabolism of L-alpha-acetylmethadol (LAAM)
Mosberg, Henry I. --- University of Michigan-College of Pharmacy
Conformation - Selectivity Relations of Opioid Peptides
Moss, Howard B. --- Western Psychiatric Institute & Clinic
Intergenerational Transmission: Substance Abuse Liability
Murphy, Edward L. --- University of California
Medical Consequences of HTLV-II in Drug Abusers
Murphy, Sheigla --- Institute for Scientific Analysis
AIDS Prevention: Needle Exchange and Ancillary Services
Nagalla, Srinivasa R. --- Oregon Health Sciences University
Xen-dorphins: A New Opioid System
Neisewander, Janet L. --- Arizona State University
Neural Mechanisms of Drug-Seeking Behavior
Noell, John W. --- Oregon Center for Applied Science, Inc.
Multimedia Program to Prevent Adolescent Sexual Coercion
Oyarce, Ana M. --- Johns Hopkins University-Dept. of Neuroscience
Translational Control of Peptidergic Enzymes by Dopamine
Patkar, Ashwin A. --- Thomas Jefferson University
Serotonergic Dysfunction and Treatment Outcome in Cocaine
Perkins, Kenneth A. --- Western Psychiatric Institute & Clinic
Discriminative Stimulus Effects of Nicotine in Humans
Pickel, Virginia M. ---Cornell University Medical College
Em-transmitter Interactions of Striatal Opioid Neurons
Pierce, Robert C. --- Washington State University
Dopamine, Calcium and Repeated Cocaine
Pintar, John E. --- University of Medicine and Dentistry-New Jersey Medical School
Genetic Studies of Opioid Receptor Function
Razdan, Raj K. --- Organix Inc.-Dept. of Research
Synthesis of Tetrahydrocannabinol Related Compounds
Reinarman, Craig --- University of California
Marijuana Use Careers and Consequences in Three Cultures
Rhodes, Fen --- Center for Behavioral Research Services
HIV Reduction for High Risk Male Drug Users
Ricaurte, George A. --- Johns Hopkins Medical Institute
Safety Assessment of Fenfluramine/Phentermine in Humans
Ries, Richard K. --- University of Washington-Harborview Medical Center
Contingent Benefits in Substance Abusing Mentally Ill
Roache, John D. --- University of Texas Health Science Center
Reinforcing Effects of Benzodiazepines in Anxiety
Roberston, Marjorie J. --- Alcohol Research Group
Drug Problem and Course of Homelessness
Robles, Rafaela R. --- University of Central De Carib
Addressing HIV Risk and Health Care Needs Under Managed Care
Roffman, Roger A. --- University of Washington-School of Social Work
Motivating Marijuana Cessation
Rohsenow, Damaris J. --- Brown University-Division of Biology and Medicine
Cocaine Craving and Coping in Treatment and Relapse
Rosenblum, Leonard A. --- State University of New York-Dept. of Psychiatry
Early Adversity and THC/Methamphetamine Vulnerability
Roth, Robert H. --- Yale University-Dept. of Pharmacology
Prenatal Cocaine Alters Cortical Dopamine Function
Roy, Alec --- East Orange VA Medical Center
Retinal Dopamine: Neurobiologic Marker in Cocaine Patients
Schulties, Gerhard H. --- VA Medical Center
CNS Delta Opioid Receptors in Pain and Drug Abuse
Seiden, Lewis S. --- University of Chicago-Pharmacology and Physiological Science
Neuropsychopharmacology Training for Drug Abuse Research
Selley, Dana E. --- Bowman Gray School of Medicine
Transduction Mechanisms of Opioid Agonist Efficacy
Sevarino, Kevin A. --- Yale University School of Medicine
The Role of PreproTRH-derived Peptides in Cocaine Action
Seybold, Virginia S. --- University of Minnesota-Dept. of Cell Biology/Neuroanatomy
Neuroscience Training in Drug Abuse Research
Sheldan, Kamel --- Arizona Institute for Biomedical Research
Neurobiology of Drug Abuse: Science Education
Sigelman, Carol K. --- George Washington University
A Theory-Centered Approach to Teaching Children about Drugs
Simon, Eric J. --- New York University Medical Center
Effects of Morphine and Analogues on Cell Metabolism
Simon, Eric J. --- New York University Medical Center-Dept. of Psychiatry
Postdoctoral Training in Research on Abused Drugs
Snyder, Solomon H. --- Johns Hopkins School of Medicine
Drug Abuse Research Center
Stevens, Sally J. --- University of Arizona-Social & Behavioral Science
Women's-Centered HIV Risk Reduction Research Study
Su, S. Susan --- National Opinion Research Center
Drug Injectors' Risk Networks and HIV Transmission
Tashkin, Donald P. --- UCLA Department of Medicine
Pulmonary Effects of Habitual Use of Marijuana
Taylor, David A. --- West Virginia University-R.S. Byrd Health Science Center
Membrane Potential and Morphine Tolerance
Turner, R. Jay --- University of Miami-Sociology Research Center
Drug Use Trajectories: Ethnic/Racial Comparisons
Walker, Ellen A. --- University of North Carolina-Dept. of Psychology
Neutral Antagonists: Functional Studies
Wang, Qiang --- East Carolina University
Metabotropic Glutamate Regulation of Amphetamine Action
Weiss, Friedbert --- Scripps Research Institute
Novel Treatments for Cocaine Dependence
Wesselmann, Ursula --- Johns Hopkins University School of Medicine-Dept. of Neurology
Opioid Modulation of Mechanisms of Uterine Pain
Wetter, David W. --- University of Texas-M.D. Anderson Cancer Center
Computer-Delivered Treatment for Smoking Cessation
Williams, Mark L. --- Nova Research Company
Intervention Efficacy Targeting Male Prostitutes
Winter, Jerrold C. --- State University of New York
Behavioral and Pharmacologic Analysis of Drug of Abuse
Wong, Dean F. --- Johns Hopkins University School of Medicine-Dept. of Radiology
Imaging Dopamine-Serotonin Mechanisms in Cocaine Craving
Wong, Mamie Mee --- Southwest Regional Lab
Patterns and Correlates of Substance Use among Mixed Heritage
Yu, Xiao-Fang --- Johns Hopkins University School of Public Health
Phenotypic/Genotypic Variation in HIV Infection
Zhang, Jianhua --- University of Cincinnati-Dept. of Cell Biology/Neuroscience
D1 Dopamine Receptor Signaling and Effects of Cocaine
Review Activities
CPDD Presentation on NIDA Review Procedures
Dr. Teresa Levitin, Director, OEPR, in collaboration with NIDA's Office of Science Policy and Communications (OSPC), presented on NIDA review procedures and chaired a "mock review" at the OSPC's grant writing workshop at the College on Problems of Drug Dependence in Nashville, TN in June. Ms. Jackie Porter of OEPR arranged the "mock review" for the workshop. At the same meeting, Dr. Levitin gave a presentation on the integration of NIDA neuroscience applications with the NIH Division of Research Grants (DRG).
Integration of NIDA's Neuroscience Applications Into the DRG Review System
Drs. Teresa Levitin and Rita Liu have continued to meet weekly with staff from the NIH Division of Research Grants (DRG) to plan the integration of NIDA's neuroscience applications into the DRG review system. Each Scientific Review Group (SRG, or "study section") at NIDA has been briefed on the plans for neuroscience integration by either Dr. Levitin, Dr. Khursheed Asghar, or Dr. William Grace of OEPR, and each SRG has been informed of upcoming activities to plan for integration of behavioral science and AIDS-related science.
NIDA Conference Grant Committee
A NIDA-wide committee formed to develop and implement procedures for the review of R13 (Conference Grant) applications met on August 11, 1997. The committee is chaired by Dr. William Grace (OEPR), and members are Drs. Cindy Miner (OSPC), Charles Sharp (DBR), Dorynne Czechowicz (DCSR), and Jamie Biswas (MDD), as well as Ms. Susan David (DEPR), Mr. Noble Jones (OoA), and Ms. Catherine Mills (GMB).
New Criteria for Research Grant Applications
NIH's announcement of new review criteria for unsolicited research grant applications has necessitated NIDA's revision of its own guidelines for, and instructions to, reviewers. OEPR staff are working with the NIH Review Policy Committee to adapt the NIH's guidelines and instructions for NIDA's use, and documents incorporating the new review criteria are being prepared for review of applications received on or after October 1, 1997. NIDA study section members have already been briefed about these new criteria, and they will be discussed again at the October/November scientific review group meetings.
New Study Sections
Plans are underway for the creation of two new study sections, one for medications development applications and one for career development applications. The career development group will review training, career development, and fellowship applications from across all NIDA scientific areas and will begin operation with the February 1, 1998 application receipt date. Dr. Mark Swieter will be the SRA for that committee. The medications
development committee will review applications for the development of new pharmacotherapies for drug abuse. Dr. Khursheed Asghar will be the SRA. These changes coincide with the integration of neuroscience applications into DRG.
Review of Center Grant Applications
Plans are underway to revise NIDA's handling of center applications. In addition to the current receipt dates of June 1 and October 1, NIDA will begin to accept applications for February 1 receipt dates, starting February of 1998. Reviewing center applications three times a year will reduce the average length of time from submission to outcome. OEPR is setting up an internal centers steering committee of program and review staff to refine the research center grant guidelines and procedures.
For additional information about NIDA send e-mail to Information@nida.nih.gov
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