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Sponsors and Collaborators: |
National Institute on Aging (NIA) Paul Beeson Faculty Scholars Program University of California, San Francisco |
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Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00099567 |
The purpose of this study is to determine if the metabolic syndrome is a risk factor for cognitive decline and if this association is modified by inflammation.
Condition |
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Cognitive Decline |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Random Sample, Prospective Study |
Official Title: | Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline |
Estimated Enrollment: | 2632 |
Study Start Date: | January 1997 |
Estimated Study Completion Date: | December 2002 |
The metabolic syndrome is a clustering of several commonly occurring disorders that include abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, and insulin resistance. This study was conducted to determine if, as hypothesized, the presence of the metabolic syndrome is associated with more cognitive decline and greater risk of developing cognitive impairment, and whether this risk is affected by the level of inflammatory markers in the blood.
This 5-year prospective observational study was conducted from 1997 to 2002 at community clinics in two locations. A total of 2632 black and white participants, aged 70 to 79 years, were recruited from the 3075 participants in the Health, Aging and Body Composition (ABC) study conducted during the same period. Participants were screened for presence of metabolic syndrome, cognitive status, inflammatory markers, and a clinic examination was administered, when the study began and at the year 3 and 5 follow-up visits.
Ages Eligible for Study: | 70 Years to 79 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Pennsylvania | |
Pittsburgh, Pennsylvania, United States | |
United States, Tennessee | |
Memphis, Tennessee, United States |
Principal Investigator: | Kristine Yaffe, MD | University of California, San Francisco |
Study ID Numbers: | IA0066, 1N01AG062106, 1R01AG021918 |
Study First Received: | December 16, 2004 |
Last Updated: | October 31, 2005 |
ClinicalTrials.gov Identifier: | NCT00099567 |
Health Authority: | United States: Federal Government |
Metabolic Syndrome Alzheimer's Disease Cognitive Impairment Inflammation |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Dementia |
Cognition Disorders Delirium Inflammation |
Disease Pathologic Processes Syndrome |