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National Cancer Institute U.S. National Institutes of Health www.cancer.gov
About DCEG

Mark E. Sherman, M.D.

Cancer Expert

Location: Executive Plaza South, Room 5028
Phone: 301-594-7661
Fax: 301-402-0916
E-mail: shermanm@mail.nih.gov

 Mark E. Sherman, M.D.

Biography

Dr. Sherman received an M.D. from the University of Chicago in 1983, completed a pathology residency at the New England Deaconess Hospital in 1987 and a fellowship in cytopathology at Montefiore Medical Center in 1988. Prior to joining the National Cancer Institute in 2001, he was an Associate Professor of Pathology and Director of Breast Pathology at The Johns Hopkins University School of Medicine.

Research Interests

  • Molecular epidemiology of gynecologic tumors and breast cancer, including studies of tissue biomarkers to compare risk factors by histopathologic type and to elucidate different mechanisms of carcinogenesis
  • Natural history of cancer precursors with emphasis on early morphologic and molecular changes
  • Hormonal carcinogenesis with emphasis on expression and actions of reproductive hormones in breast cancer
  • Development of high throughput methods for analysis of tissues, especially the development of tissue microarrays
  • Identification of biomarkers for screening and understanding imtermediate stages in carcinogenesis

Keywords

  • Breast Cancer, Gynecologic Cancer, Papillomavirus, hormonal carcinogenesis, molecular pathology

Selected Publications

  • Garcia-Closas M, Sherman ME, Brinton LA. Clarifying breast cancer risks associated with menopausal hormone therapy. Lancet Oncol 2006;7:885-6.
  • Sherman ME, Rimm DL, Yang R, Brinton LA, Lissowska J, Chatterjee N, Peplonska B, Richesson D, Hewitt S, Cartun R, Mandich D, Charette L, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Kalaylioglu Z, Rymkiewicz G, Mazepa-Sikora D, Lukaszek S, Garcia-Closas M. Automated quantitative analysis (AQUA) of ER-a, ER-b, PR and HER protein expression and established risk factors for breast cancer. Int J Cancer 2007;121:1079-85.
  • Gail MH, Anderson WF, Garcia-Closas M, Sherman ME. Absolute risk models for subtypes of breast cancer. J Natl Cancer Inst 2007; 99:1657-9. Lacey Jr JV, Ioffe O, Ronnett BM, Rush BB, Richardson D, Chatterjee N, Langholz B, Glass AG, Sherman ME. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: A 34-year experience in a large health plan. Br J Cancer 2008;98:45-53.
  • Yang XR, Pfeiffer R. Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun R, Mandich D, Sasano H, Sutter TR, Sherman ME. Hormonal markers in breast cancer: Co-expression, relationship with pathologic characteristics and risk factor associations in a population-based study. Cancer Res; 2007, 67:10608-17.
  • Lacey Jr JV, Ioffe OB, Ronnett BM, rush BB, Glass AG, Richesson DA, Chatterjee N, Langholz B, Mutter GL, Sherman ME. PTEN expression in endometrial biopsies of women who did vs. did not progress to endometrial carcinoma. Cancer Res 2008;68:6014-20.

Collaborators

DCEG Collaborators

  • Montserrat Garcia-Closas, M.D., Ph.D, Louise Brinton, Ph.D., Jonine Figueroa, Ph.D., Gretchen Gierach, Ph.D, Nicholas Wentzensen, M.D., Ph.D., Sophia Wang, Ph.D., James Lacey Jr., Ph.D., Mark Greene, M.D., William F. Anderson, M.D., Ph.D., Ph.D., Mark Greene, M.D., Susan Devesa, Ph.D.

Other NCI Collaborators

  • Diane Solomon, M.D., Barbara Vonderhaar, Ph.D., Lalage Wakefield, D. Phil, Paul Meltzer, M.D., Ph.D., Stephen Hewitt, M.D., Ph.D.

Other ScientificCollaborators

    Andrew Glass, M.D.; David Scott, M.D., Portland Kaiser-Permanente, Portland, Oregon Olga Ioffe, M.D., University of Maryland School of Medicine, Baltimore, Maryland
  • Paul Levine, M.D., George Washington University School of Public Health, Washington, D.C.
  • Jolanta Lissowska, Ph.D., Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
  • Richard Guido, M.D., Magee Women’s Hospital, Pittsburgh, PA
  • David Rimm, M.D., Ph.D., Yale University, New Haven, CT
  • Alan Meeker, Ph.D., Johns Hopkins Medical Institutions
  • Frank Stanczyk, Ph.D., University of Sothern California, Los Angeles, CA
  • Peter Laird, M.D., Ph.D., University of Sothern California, Los Angeles, CA
  • Berta Geller, Ph.D., University of Vermont, Burlington, VT
  • John Shepherd, Ph.D., University of California at San Francisco, San Francisco, CA