National Toxicology Program

Substances Recommended for Study:

• Dimorpholinodiethyl ether
• 2-Ethylhexyl p-methoxycinnamate
• 4,7,10-Trioxatridecane-1,13-diamine
• Vanadium, tetravalent and pentavalent forms

Substances studied by the NTP are selected primarily on the basis of known or anticipated human exposure, production levels, suspicion of toxicity based on chemical structure or existing health effects data, availability of toxicological data, and extent of public concern. Selection of a substance for study does not imply that the substance is hazardous or a potential carcinogen in laboratory animals; likewise, when substances are not selected for toxicological evaluation by the Program, this should not be taken to mean that the substance is not potentially hazardous or potentially carcinogenic in laboratory animals. Nominated substances in the table below are identified by a common or generic name and CAS Registry No. where appropriate.

* Note: The terms "initial toxicological characterization" and "comprehensive toxicological characterization" in this table refer to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program for each are:
-Initial toxicological characterization: biomolecular screening, in vitro mechanistic, in vitro and in vivo genotoxicity, absorption, disposition, metabolism, and elimination, and short-term repeat dose (2-4 weeks) in vivo studies
-Comprehensive toxicological characterization: all of the aforementioned plus subchronic toxicity (13-26 weeks), chronic toxicity (1-2 years), carcinogenicity in conventional or genetically modified rodent models, organ systems toxicity (immunotoxicity, reproductive and developmental toxicity, neurotoxicity), in vivo mechanistic, toxicokinetics, and other special studies as appropriate (e.g. chemistry, toxicogenomics, phototoxicity).

See here for further Description of NTP Study Types.

For information, questions or comments, contact:
Dr. Scott A. Masten
Director, Office of Nomination and Selection
National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD EC-31
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)

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