Biography
Dr. Gail received an M.D. from Harvard Medical School in 1968 and a Ph.D. in statistics from George Washington University in 1977. He joined NCI in 1969, and served as chief of the Biostatistics Branch from 1994 to 2008. Dr. Gail is a Fellow and former President of the American Statistical Association, a Fellow of the American Association for the Advancement of Science, an elected member of the American Society for Clinical Investigation, and an elected member of the Institute of Medicine of the National Academy of Sciences. He has received the Spiegelman Gold Medal for Health Statistics, the Snedecor Award for applied statistical research, the Howard Temin Award for AIDS Research, the NIH Director's Award, and the PHS Distinguished Service Medal.
Research Interests
- Developing statistical methods for epidemiologic studies, including intervention trials and genetic epidemiologic studies
- Modeling absolute risk of disease, including breast cancer risk projection
- Gastric cancer etiology, including an intervention trial to reduce the prevalence of advanced precancerous gastric lesions in Shandong Province, China
Keywords
group randomized trials, breast cancer, gastric cancer, absolute risk, attributable risk, genetic epidemiology, genetic risk
Selected Publications
- Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 2007 Nov 7;298:2028-37.
- Gail MH, Pfeiffer RM, Wheeler W, Pee D. Probability of detecting disease-associated single nucleotide polymorphisms in case-control genome-wide association studies. Biostatistics 2007 Sep 14; [Epub ahead of print]
- Gail MH, Pfeiffer RM, Brown LM, Zhang L, Ma JL, Pan KF, Liu WD, You WC. Garlic, vitamin, and antibiotic treatment for Helicobacter pylori: a randomized factorial controlled trial (letter). Helicobacter 2007;12:575-578.
- Graubard BI, Flegal KM, Williamson DF , Gail MH. Estimation of attributable number of deaths and standard errors from simple and complex sampled cohorts. Statistics in Medicine, 2007; 26: 2639-2649.
- Chen J, Pee D, Ayyagari R, Graubard B, Schairer C, Byrne C, Benichou J, Gail MH.
Projecting absolute invasive breast cancer risk in white women with a model that includes mammographic density. J Natl Cancer Inst 2006;98:1215-1226.
- You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, Ma JL, Pan KF, Liu WD, Hu Y, Crystal-Mansour S, Pee D, Blot WJ, Fraumeni JF Jr, Xu GW, Gail MH. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974-978.
- Chatterjee N, Kalaylioglu Z, Shih JH, Gail MH. Case-control and case-only designs with genotype and family history data: estimating relative risk, residual familial aggregation, and cumulative risk. Biometrics 2006;62:36-48.
- Gail MH, Pfeiffer RM. On criteria for evaluating models of absolute risk. Biostatistics 2005;6(2):227-239.
- Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005;293(15):1861-1867.
- Li Z, Gastwirth JL and Gail MH. Power and related statistical properties of conditional likelihood score tests for association studies in nuclear families with parental genotypes. Ann Hum Genet 2005;69:296-314.
- Pfeiffer RM, Goldin LR, Chatterjee N, Daugherty S, Hemminki K, Pee D, Li X, Gail MH. Methods for testing familial aggregation of diseases in population-based samples: application to hodgkin lymphoma in swedish registry data. Ann Hum Genet 2004;68(Pt 5):498-508.
- Freedman AN, Graubard BI, Rao SR, McCaskill-Stevens W, Ballard-Barbash R, Gail MH. Estimates of the number of US women who could benefit from tamoxifen for breast cancer chemoprevention. Natl Cancer Inst 2003;95(7):526-32.
- Gail MH, Chatterjee N. "Some biases that may affect kin-cohort studies for estimating the risks from identified disease genes." In: Proceeding of the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data ( Lin DY and Haegerty PY, eds) Springer, New York 2004;175-186.
- Pfeiffer RM, Gail MH. Sample Size Calculations for Population- and Family-Based Case-Control Association Studies on Marker Genotypes. Genetic Epidemiology 2003;25:136-148.
Collaborators
DCEG Collaborators
- Linda Brown, Dr.P.H.; Nilanjan Chatterjee, Ph.D.; Susan Devesa, Ph.D.;Thomas Fears, Ph.D.; Mark H. Greene, M.D.; Gloria Gridley, M.S.; Ruth Pfeiffer, Ph.D.; Catherine Schairer, Ph.D.
Other NCI Collaborators
- Lin Clegg, Ph.D.; Rocky Feuer, Ph.D.
Other Scientific Collaborators
- Jacques Benichou, M.D., Ph.D, University of Rouen Medical School, Rouen, France
- Celia Byrne, Ph.D., Harvard Medical School, Boston, MA
- Raymond Carroll, Ph.D., Texas A&M University, College Station, TX
- Joseph Costantino, Ph.D., Univ. of Pittsburgh, Pittsburgh, PA
- Joseph Gastwirth, Ph.D., George Washington University, Washington, DC
- Laurence Freedman, Ph.D., Bar IIan University, Ramat Gan, Israel
- Zongtang Sun, M.D., Chinese Academy of Medical Sciences, Beijing, China
- Hans van Houwelingen, Ph.D., Leiden University, Leiden, The Netherlands
- Wei Cheng You, M.D., Beijing Institute of Cancer Research, Beijing, China
- Zhaohai Li, George Washington University, Washington, DC
- Hongyu Zhao, Ph.D., Yale University, New Haven, CT