Map histone modifications using chromatin immunoprecipitation followed by high-throughput sequencing.
Gregory Crawford
Duke University
Identify and characterize regions of open chromatin using DNaseI hypersensitivity assays, formaldehyde-assisted isolation of regulatory elements, and chromatin immunoprecipitation.
Thomas Gingeras
Affymetrix, Inc.
Identify protein-coding and non-protein coding RNA transcripts using microarrays, high-throughput sequencing, sequence paired-end tags, and sequenced cap analysis of gene expression tags.
Timothy Hubbard
Wellcome Trust Sanger Institute
Annotate gene features using computational methods, manual annotation, and targeted experiments.
Richard Myers
Stanford University
Identify transcription factor binding sites using chromatin immunoprecipitation followed by high-throughput DNA sequencing; Pilot effort to determine the methylation status of CpG-rich regions.
Michael Snyder
Yale University
Identify transcription factor binding sites using chromatin immunoprecipitation followed by high-throughput DNA sequencing.
John Stamatoyannopoulos
University of Washington, Seattle
Map and functionally classify DNaseI hypersensitive sites by digital DNaseI and histone modification mapping using high-throughput sequencing.
Develop high-throughput methods to predict functional motifs in RNA, to map RNA structure, and to assign biological functions to RNA motifs.
Michael Dorschner
University of Washington, Seattle
Develop an in vivo method for identifying sites of protein-DNA interaction using cleavage sensitivity with UV light, dimethylsulfate, and DNaseI followed by single molecule sequencing.
John Greally
Albert Einstein College of Medicine
Develop high-throughput methods to analyze cytosine methylation and map histone modifications.
Xiaoman Li
Indiana University
Develop computational methods for identifying conserved cis-regulatory modules in non-protein coding regions.
Marcelo Nobrega
University of Chicago
Develop tagged DNA binding proteins that are recognizable by tag-specific antibodies; Develop platforms to test predicted enhancers, silencers and insulators.
Yijun Ruan
Genome Institute of Singapore
Develop methods that use high-throughput sequencing to characterize long-range chromatin interactions involved in transcription.